慢性乙型肝炎中的缺血性心脏病：一项丹麦全国性队列研究。

Ischemic Heart Disease in Chronic Hepatitis B: A Danish Nationwide Cohort Study.

作者信息

Lau Frederik Faergemann, Bollerup Signe, Engsig Frederik, Krarup Henrik, Mygind Lone Hagens, Hansen Jesper Bach, Madsen Lone Galmstrup, Thielsen Peter, Balslev Ulla, Nielsen Lars Nørregaard, Barfod Toke S, Clausen Mette Rye, Hobolth Lise, Laursen Alex Lund, Tarp Britta, Roege Birgit T, Gerstoft Jan, Christensen Peer Brehm, Weis Nina

机构信息

Department of Infectious Diseases, Copenhagen University Hospital-Hvidovre, Hvidovre, Denmark.

Department of Molecular Diagnostics, Aalborg University Hospital, Aalborg, Denmark.

出版信息

Clin Epidemiol. 2022 Jul 18;14:879-888. doi: 10.2147/CLEP.S361910. eCollection 2022.

DOI:10.2147/CLEP.S361910

PMID:35879942

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9307867/

Abstract

OBJECTIVE

Data on the risk of ischemic heart disease (IHD) in patients with chronic hepatitis B virus (CHB) are conflicting. Our objective was to address the rate of IHD in patients with CHB compared with individuals without CHB (control-persons) from the general population.

STUDY DESIGN AND SETTING

We conducted a cohort study of prospectively obtained data from Danish nationwide registries. We produced cumulative incidence curves and calculated the unadjusted incidence rate ratio (IRR) of IHD in persons with and without CHB. The adjusted association between having CHB and developing IHD was examined using a cause-specific Cox regression model.

RESULTS

In total, 6472 persons with CHB and 62,251 age- and sex-matched individuals from the general population were followed for 48,840 and 567,456 person-years, respectively, during which 103 (1,59%) with CHB and 1058 (1,70%) control-persons developed IHD. The crude IRR was 1.13 (95% CI: 0.91-1.39). CHB did not have a statistically significant effect on the rate of IHD after adjusting for several confounding factors (adjusted hazard ratio: 0.96, 95% CI: 0.76-1.21).

CONCLUSION

In this nationwide cohort study, we did not find any difference between rate of IHD in persons with CHB in comparison with the general population.

摘要

目的

慢性乙型肝炎病毒（CHB）患者缺血性心脏病（IHD）风险的数据存在矛盾。我们的目的是探讨CHB患者与普通人群中无CHB者（对照人群）相比的IHD发生率。

研究设计与设置

我们对丹麦全国登记处前瞻性获取的数据进行了队列研究。我们绘制了累积发病率曲线，并计算了有和无CHB者IHD的未调整发病率比（IRR）。使用特定病因的Cox回归模型检验CHB与发生IHD之间的校正关联。

结果

总共对6472例CHB患者和62251例来自普通人群的年龄和性别匹配个体分别进行了48840和567456人年的随访，在此期间，103例（1.59%）CHB患者和1058例（1.70%）对照人群发生了IHD。粗IRR为1.13（95%CI：0.91-1.39）。在调整了几个混杂因素后，CHB对IHD发生率没有统计学上的显著影响（校正风险比：0.96，95%CI：0.76-1.21）。