Zhang Li, Wu Hong-Di, Qian Yuan-Fang, Xu Hong-Yan
Department of Infectious Diseases, Tongde Hospital of Zhejiang Province, Hangzhou 310012, Zhejiang Province, China.
Department of Nursing, Tongde Hospital of Zhejiang Province, Hangzhou 310012, Zhejiang Province, China.
World J Clin Cases. 2024 Sep 6;12(25):5749-5760. doi: 10.12998/wjcc.v12.i25.5749.
The prevalence of nonalcoholic fatty liver disease (NAFLD) in patients with chronic hepatitis B (CHB) has increased in recent clinical practice; however, the relationship between CHB and hepatic steatosis (HS) remains controversial.
To shed light on the potential association between NAFLD and hepatitis B virus (HBV) infection.
We conducted a systematic literature search using multiple databases, including PubMed, the Cochrane Library, Web of Science, and EMBASE, to identify relevant studies. Predefined inclusion criteria were used to determine the eligibility of the studies for further analysis.
Comprehensive meta-analysis software was used for statistical analysis, which covered 20 studies. The results indicated a lower NAFLD susceptibility in HBV-infected individuals (pooled OR = 0.87; 95%CI = 0.69-1.08; = 91.1%), with diabetes ( = 0.015), body mass index (BMI; = 0.010), and possibly age ( = 0.061) as heterogeneity sources. Of note, in four studies (6197 HBV patients), HBV-infected individuals had a reduced NAFLD risk (OR = 0.68, 95%CI = 0.51-0.89, = 0.006). A positive link between hyperlipidemia and metabolic syndrome emerged in hepatitis B patients, along with specific biochemical indicators, including BMI, creatinine, uric acid, fasting blood glucose, and homeostasis model assessment of insulin resistance.
HBV infection may provide protection against HS; however, the occurrence of HS in patients with HBV infection is associated with metabolic syndrome and specific biochemical parameters.
在最近的临床实践中，慢性乙型肝炎（CHB）患者中非酒精性脂肪性肝病（NAFLD）的患病率有所增加；然而，CHB与肝脂肪变性（HS）之间的关系仍存在争议。
阐明NAFLD与乙型肝炎病毒（HBV）感染之间的潜在关联。
我们使用多个数据库进行了系统的文献检索，包括PubMed、Cochrane图书馆、Web of Science和EMBASE，以识别相关研究。使用预定义的纳入标准来确定研究是否符合进一步分析的条件。
使用综合荟萃分析软件进行统计分析，共纳入20项研究。结果表明，HBV感染个体的NAFLD易感性较低（合并OR = 0.87；95%CI = 0.69 - 1.08；I² = 91.1%），异质性来源包括糖尿病（I² = 0.015）、体重指数（BMI；I² = 0.010），可能还有年龄（I² = 0.061）。值得注意的是，在四项研究（6197例HBV患者）中，HBV感染个体的NAFLD风险降低（OR = 0.68，95%CI = 0.51 - 0.89，P = 0.006）。在乙型肝炎患者中，高脂血症与代谢综合征之间出现了正相关，同时还与特定的生化指标相关，包括BMI、肌酐、尿酸、空腹血糖和胰岛素抵抗的稳态模型评估。
HBV感染可能对HS具有保护作用；然而，HBV感染患者中HS的发生与代谢综合征和特定的生化参数有关。
