Fitzpatrick F A, Stringfellow D A
Proc Natl Acad Sci U S A. 1979 Apr;76(4):1765-9. doi: 10.1073/pnas.76.4.1765.
B16 malignant melanoma cell lines transform arachidonic acid and its transient metabolite, prostaglandin endoperoxide H2, into prostaglandin D2. The highly metastatic line, B16 F10, forms less prostaglandin D2 compared to the moderately metastatic parent line, B16 F1. Since platelet aggregation may be one factor involved in B16 metastasis and since prostaglandin D2 inhibits platelet aggregation, this prostaglandin could affect the outcome of platelet-tumour interactions, which may contribute ultimately to metastasis. Arachidonic acid metabolism may be another one of the intrinsic biochemical properties of tumor cells that affects their metastasis. Our results suggest that quantitative release of unusual prostaglandins must be considered in this context.
B16恶性黑色素瘤细胞系将花生四烯酸及其瞬时代谢产物前列腺素内过氧化物H2转化为前列腺素D2。高转移性细胞系B16 F10与中度转移性亲代细胞系B16 F1相比，产生的前列腺素D2较少。由于血小板聚集可能是B16转移涉及的一个因素，且前列腺素D2可抑制血小板聚集，因此这种前列腺素可能影响血小板与肿瘤相互作用的结果，这最终可能有助于转移。花生四烯酸代谢可能是影响肿瘤细胞转移的肿瘤细胞内在生化特性之一。我们的结果表明，在这种情况下必须考虑异常前列腺素的定量释放。
