Agnihotri Mona A, Kothari Kanchan S, Naik Leena P, Patil Sharada
Department of Pathology, Seth GS Medical College and King Edward Memorial Hospital, Mumbai, Maharashtra, India.
J Cytol. 2017 Jul-Sep;34(3):165-167. doi: 10.4103/0970-9371.208101.
Anaplastic large cell lymphoma (ALCL) is a T-cell lymphoma, accounting for <5% of non-Hodgkin's lymphoma. Cutaneous involvement can be primary or secondary arising in systemic ALCL. The diagnostic feature in both is the presence of pleomorphic, CD30 positive hallmark cells. We present a case of ALCL in a 19-year-old male presenting as an ulcerated scalp swelling. Clinical impression was actinomycosis or scrofuloderma. Cytology smears showed large dispersed pleomorphic cells with hyperlobated nuclei and multinucleated giant cells. The differentials considered were ALCL, rhabdomyosarcoma, and poorly differentiated carcinoma. Immunocytochemistry (ICC) showed positivity for leukocyte common antigen (LCA) and CD30 while negativity for desmin, favoring ALCL. Computed tomography (CT) showed a lytic paravertebral lesion. Subsequently, both paraspinal and scalp lesions were biopsied and immunochemistry confirmed the diagnosis of ALCL. Thus, cutaneous involvement in ALCL can resemble inflammatory and other neoplastic lesions clinically and cytologically. Hence, a high index of suspicion and ICC can aid in the correct diagnosis on fine needle aspiration cytology (FNAC).
间变性大细胞淋巴瘤(ALCL)是一种T细胞淋巴瘤,占非霍奇金淋巴瘤的比例不到5%。皮肤受累可为原发性,也可继发于系统性ALCL。两者的诊断特征均为存在多形性、CD30阳性的标志性细胞。我们报告一例19岁男性的ALCL病例,表现为头皮溃疡肿胀。临床诊断为放线菌病或瘰疬性皮肤结核。细胞学涂片显示有大的散在多形性细胞,核呈分叶状,还有多核巨细胞。鉴别诊断考虑为ALCL、横纹肌肉瘤和低分化癌。免疫细胞化学(ICC)显示白细胞共同抗原(LCA)和CD30呈阳性,而结蛋白呈阴性,支持ALCL的诊断。计算机断层扫描(CT)显示椎旁有溶骨性病变。随后,对椎旁和头皮病变均进行了活检,免疫化学确诊为ALCL。因此,ALCL的皮肤受累在临床和细胞学上可能类似于炎症性和其他肿瘤性病变。因此,高度的怀疑指数和ICC有助于在细针穿刺细胞学检查(FNAC)中做出正确诊断。