Khatiwada Saroj, Sah Santosh Kumar, Kc Rajendra, Baral Nirmal, Lamsal Madhab
Department of Pharmacy, Central Institute of Science and Technology (CIST) College, Pokhara University, Kathmandu, Nepal.
Department of Biochemistry, Universal College of Medical Sciences, Bhairahawa, Nepal.
Clin Diabetes Endocrinol. 2016 Feb 1;2:3. doi: 10.1186/s40842-016-0021-0. eCollection 2016.
A growing body of evidence suggests that metabolic syndrome is associated with endocrine disorders including thyroid dysfunction. Thyroid dysfunction in metabolic syndrome patients may further add to cardiovascular disease risk thereby increasing mortality. This study was done to assess thyroid function in metabolic syndrome patients and evaluate its relationship with the components of metabolic syndrome.
A cross sectional study was carried out among 169 metabolic syndrome patients at B P Koirala Institute of Health Sciences, Dharan, Nepal. Anthropometric measurements (height, weight, waist circumference) and blood pressure were taken. Fasting blood samples were analysed to measure glucose, triglyceride, high density lipoprotein (HDL) cholesterol and thyroid hormones (triiodothyronine, thyroxine and thyroid stimulating hormone).
Thyroid dysfunction was seen in 31.9 % ( = 54) metabolic syndrome patients. Subclinical hypothyroidism (26.6 %) was the major thyroid dysfunction followed by overt hypothyroidism (3.5 %) and subclinical hyperthyroidism (1.7 %). Thyroid dysfunction was much common in females (39.7 %, = 29) than males (26 %, = 25) but not statistically significant ( = 0.068). The relative risk of having thyroid dysfunction in females was 1.525 (CI: 0.983-2.368) as compared to males. Significant differences ( = 0.001) were observed in waist circumference between patients with and without thyroid dysfunction and HDL cholesterol which had significant negative correlation with thyroid stimulating hormone.
Thyroid dysfunction, particularly subclinical hypothyroidism is common among metabolic syndrome patients, and is associated with some components of metabolic syndrome (waist circumference and HDL cholesterol).
越来越多的证据表明，代谢综合征与包括甲状腺功能障碍在内的内分泌紊乱有关。代谢综合征患者的甲状腺功能障碍可能会进一步增加心血管疾病风险，从而提高死亡率。本研究旨在评估代谢综合征患者的甲状腺功能，并评估其与代谢综合征各组分的关系。
在尼泊尔达兰的BP柯伊拉腊健康科学研究所，对169例代谢综合征患者进行了一项横断面研究。测量了人体测量学指标（身高、体重、腰围）和血压。采集空腹血样，分析血糖、甘油三酯、高密度脂蛋白（HDL）胆固醇和甲状腺激素（三碘甲状腺原氨酸、甲状腺素和促甲状腺激素）。
31.9%（n = 54）的代谢综合征患者存在甲状腺功能障碍。亚临床甲状腺功能减退（26.6%）是主要的甲状腺功能障碍，其次是显性甲状腺功能减退（3.5%）和亚临床甲状腺功能亢进（1.7%）。甲状腺功能障碍在女性（39.7%，n = 29）中比男性（26%，n = 25）更常见，但差异无统计学意义（P = 0.068）。女性发生甲状腺功能障碍的相对风险为1.525（95%置信区间：0.983 - 2.368），高于男性。甲状腺功能障碍患者与无甲状腺功能障碍患者的腰围以及与促甲状腺激素呈显著负相关的HDL胆固醇存在显著差异（P = 0.001）。
甲状腺功能障碍，尤其是亚临床甲状腺功能减退在代谢综合征患者中很常见，并且与代谢综合征的某些组分（腰围和HDL胆固醇）有关。
