Jalalonmuhali Maisarah, Kok Peng Ng, Soo Kun Lim
University Malaya Medical Centre, 59100 Kuala Lumpur, Malaysia.
Int J Nephrol. 2017;2017:2901581. doi: 10.1155/2017/2901581. Epub 2017 Jun 18.
To validate the accuracy of estimated glomerular filtration rate (eGFR) equations in Malay population attending our hospital in comparison with radiolabeled measured GFR.
A cross-sectional study recruiting volunteered patients in the outpatient setting. Chromium EDTA (51Cr-EDTA) was used as measured GFR. The predictive capabilities of Cockcroft-Gault equation corrected for body surface area (CGBSA), four-variable Modification of Diet in Renal Disease (4-MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations were calculated.
A total of 51 subjects were recruited with mean measured GFR 42.04 (17.70-111.10) ml/min/1.73 m. Estimated GFR based on CGBSA, 4-MDRD, and CKD-EPI were 40.47 (16.52-115.52), 35.90 (14.00-98.00), and 37.24 (14.00-121.00), respectively. Higher accuracy was noted in 4-MDRD equations throughout all GFR groups except for subgroup of GFR ≥ 60 ml/min/1.73 m where CGBSA was better.
The 4-MDRD equation seems to perform better in estimating GFR in Malay CKD patients generally and specifically in the subgroup of GFR < 60 ml/min/1.73 m and both BMI subgroups.
与放射性标记测量的肾小球滤过率（GFR）相比，验证我院马来族人群中估算肾小球滤过率（eGFR）方程的准确性。
在门诊环境中招募志愿者患者进行横断面研究。使用铬标记乙二胺四乙酸（51Cr-EDTA）作为测量的GFR。计算经体表面积校正的Cockcroft-Gault方程（CGBSA）、四变量肾病饮食改良方程（4-MDRD）和慢性肾脏病流行病学协作组（CKD-EPI）方程的预测能力。
共招募了51名受试者，平均测量的GFR为42.04（17.70 - 111.10）ml/min/1.73m²。基于CGBSA、4-MDRD和CKD-EPI估算的GFR分别为40.47（16.52 - 115.52）、35.90（14.00 - 98.00）和37.24（14.00 - 121.00）。在所有GFR组中，除了GFR≥60 ml/min/1.73m²亚组中CGBSA表现更好外，4-MDRD方程在其他组的准确性更高。
4-MDRD方程在估算马来族慢性肾脏病患者的GFR方面总体表现更好，特别是在GFR < 60 ml/min/1.73m²亚组以及两个BMI亚组中。
