肺炎球菌对大环内酯类药物的耐药性——这有关系吗？
Macrolide resistance in pneumococci-is it relevant?
作者信息
Cheng Allen C, Jenney Adam W J
机构信息
Infection Prevention and Healthcare Epidemiology Unit, Melbourne, Australia.
School of Public Health and Preventive Medicine, Melbourne, Australia.
出版信息
Pneumonia (Nathan). 2016 Jul 7;8:10. doi: 10.1186/s41479-016-0010-1. eCollection 2016.
Abstract
Macrolide antibiotics are widely used for a range of indications, including pneumonia. Both high-level and low-level resistance to macrolides is increasing in pneumococci globally. Macrolide resistance in pneumococci is of limited clinical relevance where ß-lactams remain the mainstay of treatment, such as for moderate/severe pneumonia; however, data suggest that macrolides may not be able to be relied on as monotherapy for serious pneumococcal infections.
摘要
大环内酯类抗生素广泛用于一系列适应症，包括肺炎。全球肺炎球菌对大环内酯类抗生素的高水平和低水平耐药性都在增加。在β-内酰胺类药物仍是主要治疗药物的情况下，如治疗中度/重度肺炎，肺炎球菌对大环内酯类药物的耐药性临床相关性有限；然而，数据表明，大环内酯类药物可能无法作为严重肺炎球菌感染的单一疗法。
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