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Treatment of refractory and severe hypothyroidism with sublingual levothyroxine in liquid formulation.

作者信息

Peirce Carmela, Ippolito Serena, Lanas Alejandra, Pesce Marcella, Pontieri Gilda, Arpaia Debora, Sarnelli Giovanni, Biondi Bernadette

机构信息

Department of Clinical Medicine and Surgery, University of Naples Federico II, Via Pansini 5, 80131, Naples, Italy.

出版信息

Endocrine. 2018 Apr;60(1):193-196. doi: 10.1007/s12020-017-1367-5. Epub 2017 Jul 13.

DOI:10.1007/s12020-017-1367-5
PMID:28702889
Abstract
摘要

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Treatment of refractory and severe hypothyroidism with sublingual levothyroxine in liquid formulation.采用液体制剂的舌下左甲状腺素治疗难治性重度甲状腺功能减退症。
Endocrine. 2018 Apr;60(1):193-196. doi: 10.1007/s12020-017-1367-5. Epub 2017 Jul 13.
2
A case of refractory hypothyroidism requiring daily intravenous thyroxine.一例需要每日静脉注射甲状腺素的难治性甲状腺功能减退症病例。
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Estimation of a physiologic replacement dose of levothyroxine in elderly patients with hypothyroidism.老年甲状腺功能减退患者左甲状腺素生理替代剂量的估算。
Arch Intern Med. 1984 Sep;144(9):1752-4.
4
Levothyroxine in subclinical hypothyroidism: a lifelong therapy?亚临床甲状腺功能减退症中的左甲状腺素：一种终身治疗方法？
Clin Endocrinol (Oxf). 2010 May;72(5):718-20. doi: 10.1111/j.1365-2265.2009.03711.x. Epub 2009 Sep 21.
5
Pharmacotherapy: hypothyroidism-should levothyroxine be taken at bedtime?药物治疗：甲状腺功能减退症——左甲状腺素应该在睡前服用吗？
Nat Rev Endocrinol. 2011 Apr;7(4):195-6. doi: 10.1038/nrendo.2011.29. Epub 2011 Mar 1.
6
Serum thyrotropin in primary hypothyroidism. A possible predictor of optimal daily levothyroxine dose in primary hypothyroidism.原发性甲状腺功能减退症中的血清促甲状腺激素。原发性甲状腺功能减退症中每日左甲状腺素最佳剂量的一个可能预测指标。
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N Engl J Med. 2004 Jul 15;351(3):241-9. doi: 10.1056/NEJMoa040079.
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Serum thyroid hormone and thyrotropin concentrations during thyroxine and triiodothyronine therapy.甲状腺素和三碘甲状腺原氨酸治疗期间的血清甲状腺激素和促甲状腺激素浓度。
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[Primary hypothyroidism: Considerations for a rational use of levothyroxine therapy].[原发性甲状腺功能减退症：左甲状腺素治疗合理应用的考量]
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Subclinical hypothyroidism. To treat or not to treat.亚临床甲状腺功能减退症。治疗还是不治疗。
Can Fam Physician. 1993 Sep;39:1997-8, 2001-3.

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Association of LncRNA-PAX8-AS1 and LAIR-2 polymorphisms along with their expression with clinical and subclinical hypothyroidism.

本文引用的文献

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IN PATIENTS WITH SUBCLINICAL HYPOTHYROIDISM WHILE IN THERAPY WITH TABLET L-T4, THE LIQUID L-T4 FORMULATION IS MORE EFFECTIVE IN RESTORING EUTHYROIDISM.在接受左旋甲状腺素片治疗的亚临床甲状腺功能减退症患者中，液体左旋甲状腺素制剂在恢复甲状腺功能正常方面更有效。
Endocr Pract. 2017 Feb;23(2):170-174. doi: 10.4158/EP161545.OR. Epub 2016 Nov 16.
2
Advancements in the treatment of hypothyroidism with L-T4 liquid formulation or soft gel capsule: an update.左甲状腺素液体剂型或软胶囊治疗甲状腺功能减退症的进展：最新情况
Expert Opin Drug Deliv. 2017 May;14(5):647-655. doi: 10.1080/17425247.2016.1227782. Epub 2016 Aug 30.
3
Liquid and softgel levothyroxine use in clinical practice: state of the art.
LncRNA-PAX8-AS1 和 LAIR-2 多态性及其表达与临床和亚临床甲状腺功能减退症的关联。
Sci Rep. 2023 Jan 2;13(1):6. doi: 10.1038/s41598-022-26346-0.
4
Levothyroxine: Conventional and Novel Drug Delivery Formulations.左甲状腺素：常规和新型药物制剂。
Endocr Rev. 2023 May 8;44(3):393-416. doi: 10.1210/endrev/bnac030.
5
Levothyroxine Therapy in Thyrodectomized Patients.甲状腺切除术患者的左甲状腺素治疗。
Front Endocrinol (Lausanne). 2021 Jan 29;11:626268. doi: 10.3389/fendo.2020.626268. eCollection 2020.
6
The Human Microbiota in Endocrinology: Implications for Pathophysiology, Treatment, and Prognosis in Thyroid Diseases.《内分泌学中的人类微生物群：甲状腺疾病的病理生理学、治疗和预后意义》。
Front Endocrinol (Lausanne). 2020 Dec 4;11:586529. doi: 10.3389/fendo.2020.586529. eCollection 2020.
7
Novel thyroxine formulations: a further step toward precision medicine.新型甲状腺素制剂：精准医学的又一步。
Endocrine. 2019 Oct;66(1):87-94. doi: 10.1007/s12020-019-02049-x. Epub 2019 Oct 15.
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Levothyroxine Therapy: Changes of TSH Levels by Switching Patients from Tablet to Liquid Formulation. A Systematic Review and Meta-Analysis.左甲状腺素治疗：患者从片剂转换为液体制剂时促甲状腺激素水平的变化。一项系统评价与荟萃分析。
Front Endocrinol (Lausanne). 2018 Jan 26;9:10. doi: 10.3389/fendo.2018.00010. eCollection 2018.
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Switching levothyroxine from the tablet to the oral solution formulation corrects the impaired absorption of levothyroxine induced by proton-pump inhibitors.将左甲状腺素从片剂转换为口服液体制剂可纠正质子泵抑制剂引起的左甲状腺素吸收不良。
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The administration of L-thyroxine as soft gel capsule or liquid solution.左甲状腺素的给药途径可以是软胶囊或液体制剂。
Expert Opin Drug Deliv. 2014 Jul;11(7):1103-11. doi: 10.1517/17425247.2014.918101. Epub 2014 Jun 4.
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Treatment with thyroid hormone.甲状腺激素治疗。
Endocr Rev. 2014 Jun;35(3):433-512. doi: 10.1210/er.2013-1083. Epub 2014 Jan 16.
10
A novel formulation of L-thyroxine (L-T4) reduces the problem of L-T4 malabsorption by coffee observed with traditional tablet formulations.一种新型的左甲状腺素（L-T4）配方减少了与传统片剂配方相比，咖啡引起的 L-T4 吸收不良的问题。
Endocrine. 2013 Feb;43(1):154-60. doi: 10.1007/s12020-012-9772-2. Epub 2012 Aug 30.