Aragona S E, Grassi F R, Nardi G, Lotti J, Mereghetti G, Canavesi E, Equizi E, Puccio A M, Lotti T
Regenerative Medicine Centre, Humanitas Mater Domini, Castellanza, Varese, Italy.
Department of Interdisciplinary Medicine, University of Bari, Bari, Italy.
J Biol Regul Homeost Agents. 2017;31(2 Suppl. 2):213-218.
In recent decades, regenerative medicine has achieved an important evolution at both a conceptual level and scientific production, which explains the current and future possibilities of therapy and daily clinical practice. The main aim of regenerative medicine is the complex system of repair/regeneration. The current literature on the subject demonstrates the advantage of visible light therapy for skin injuries and diseases with the photobiomodulation in which light at low energy levels modulates intra- and extra-cellular photoreceptors by molecular and cellular processes that can stimulate both anti-inflammatory mechanisms and cell proliferative response. The irradiation effects are activated soon after exposure. The anti-inflammatory action on some classes of cytokines and cells (e.g. mast cells and macrophages) is completed with the stimulation of the nitric oxide production, which has an anti-inflammatory and vasodilation action, and gives analgesic relief. Our attention focused on photobiomodulator medical device emitting polarized light. 30 patients (19 women and 11 men) were enrolled in the present study. They were treated for chronic lesions using Bioptron® Light Therapy System device. Patients were initially subjected to Bioptron® light for 20 min after cleansing of the lesion. The operating protocol provides 24 sessions: twice per week for 12 weeks. Twenty patients have been studied for symptoms, histological samples and ulcer characteristics. After 2 months, a reduction of 50% of the lesions was recorded in 18 patients (60%), while in the remaining patients a slower healing was observed. The total wound healing was achieved after 3 months in 13 patients (43%). The examined parameters of the symptom were exudation, pain and signs of infection. Results at 1 and 3 months were, Exudation: at 1 month reduction and positive modulation was observed in 16 patients (53%) and in 25 patients at 3 months; Pain: (evaluated with Vas scale), decreased in 21 patients at 1 month (70%) and in 100% of cases at 3 months; Infections: regressed or disappeared in 100% of cases after the first month. Today, it is no longer time for monotherapy applications, especially in regenerative medicine and the adoption of biophysical therapies can play a positive anti-inflammatory and regenerative role enhancing the function of non-invasive therapies.
近几十年来，再生医学在概念层面和科研成果方面都取得了重大进展，这也解释了当前及未来治疗和日常临床实践的可能性。再生医学的主要目标是复杂的修复/再生系统。目前关于该主题的文献表明，可见光疗法对皮肤损伤和疾病具有优势，其通过光生物调节作用，低能量水平的光通过分子和细胞过程调节细胞内和细胞外的光感受器，从而刺激抗炎机制和细胞增殖反应。照射效果在暴露后很快就会被激活。对某些细胞因子和细胞（如肥大细胞和巨噬细胞）的抗炎作用通过刺激一氧化氮的产生来完成，一氧化氮具有抗炎和血管舒张作用，并能缓解疼痛。我们的注意力集中在发射偏振光的光生物调节医疗设备上。本研究招募了30名患者（19名女性和11名男性）。他们使用Bioptron®光疗系统设备治疗慢性损伤。患者在清洁损伤部位后，最初接受Bioptron®光照射20分钟。操作方案为24次治疗：每周两次，共12周。对20名患者的症状、组织样本和溃疡特征进行了研究。2个月后，18名患者（60%）的损伤减少了50%，而其余患者的愈合速度较慢。13名患者（43%）在3个月后实现了伤口完全愈合。所检查的症状参数包括渗出、疼痛和感染迹象。1个月和3个月时的结果如下：渗出：1个月时，16名患者（53%）出现减少和正向调节，3个月时为25名患者；疼痛：（采用视觉模拟评分法评估），1个月时21名患者（70%）疼痛减轻，3个月时所有病例均减轻；感染：第一个月后100%的病例消退或消失。如今，单一疗法的应用时代已经过去，尤其是在再生医学领域，采用生物物理疗法可以发挥积极的抗炎和再生作用，增强非侵入性疗法的功能。
