Aragona S E, Mereghetti G, Lotti J, Vosa A, Lotti T, Canavesi E
Regenerative Medicine Centre, Humanitas Mater Domini, Castellanza, Varese, Italy.
Department of Nuclear, Subnuclear and Radiation Physics, University of Rome "G. Marconi", Rome, Italy.
J Biol Regul Homeost Agents. 2017;31(2 Suppl. 2):219-225.
In scientific literature, magnetic fields are used both in basic science and clinical research. They are often used to treat pain and neuro-inflammation disorders thanks to their influence on cellular responses. Our project was born from the regenerative support that we wanted to give to those diseases characterized by neuro-inflammation, nerve lesion, muscles and tissues disorders that can transform the symptom (e.g. neuropathic pelvic pain) in disease. In this study, we examined the action of pulsed electromagnetic fields (PEMFs) on skin lesion regeneration and the repetitive trans-pelvic magnetic stimulation (rTPMS) on patients affected by incontinence and post-surgical problems, sexual dysfunction, and pelvic pain. In rTPMS for post-surgery urinary incontinence, 40 patients affected by post-surgery urinary incontinence were enrolled. Twenty patients (post-prostatectomy) were treated with rTPMS and 20 with conventional therapies. In PEMF for the regeneration of skin tissue, 50 patients affected by various types of skin lesions (70% low legs vascular lesions) were treated with pulsed electromagnetic fields (PEMFs) twice per week and subsequently with home treatment (Home Care device) twice per day. In rTPMS study, results were evaluated after 3 months. In 10 patients (7 post prostatectomy, 3 cystourethrocele) which were submitted to 18 sessions, twice a week, an improvement of incontinence in 75% of cases with patient compliance was recorded and the quality of life up to 100% also improved. Utilizing PEMFs for the regeneration of skin tissue, following 3 months of AIMED protocol treatment, we reached a reduction of 50% of lesion area in the 60% of cases; 35% of cases healed completely. The use of rTPMS allows training muscles to adequately respond to inflammatory stimulus that causes muscle accommodation deficits with altered contractility or spastic painful contracture in pelvic district. It also stimulates a series of regenerative phenomena due to the action of magnetic waves at high intensity on cellular membrane and cytoplasm, especially on mast cells, which seem to have a fundamental role in the determination of the pelvic r egion pain. The magnetic fields for the treatment of cutaneous lesions, which are applied cyclically with other operating methods of AIMED protocol, confirmed the literature data, with a treated group of 50 patients. The use of magnetic fields opens new scenarios for regenerative medicine, since the cell could lend itself to a self-healing process if it receives specific information.
在科学文献中，磁场被应用于基础科学和临床研究。由于其对细胞反应的影响，磁场常被用于治疗疼痛和神经炎症性疾病。我们的项目源于我们想要为那些以神经炎症、神经损伤、肌肉和组织紊乱为特征的疾病提供再生支持，这些疾病可能会将症状（如神经性盆腔疼痛）转变为疾病。在本研究中，我们研究了脉冲电磁场（PEMF）对皮肤损伤再生的作用，以及重复经盆腔磁刺激（rTPMS）对尿失禁、术后问题、性功能障碍和盆腔疼痛患者的影响。在针对术后尿失禁的rTPMS研究中，招募了40名受术后尿失禁影响的患者。20名患者（前列腺切除术后）接受了rTPMS治疗，20名患者接受了传统治疗。在用于皮肤组织再生的PEMF研究中，50名受各种类型皮肤损伤影响的患者（70%为小腿血管损伤）每周接受两次脉冲电磁场（PEMF）治疗，随后每天进行两次家庭治疗（家庭护理设备）。在rTPMS研究中，3个月后评估结果。在10名接受了每周两次共18次治疗的患者（7名前列腺切除术后患者，3名膀胱尿道膨出患者）中，记录到75%的患者在患者依从性良好的情况下尿失禁得到改善，生活质量也提高了100%。在使用PEMF进行皮肤组织再生的研究中，经过3个月的AIMED方案治疗后，60%的病例中病变面积减少了50%；35%的病例完全愈合。rTPMS的使用可以训练肌肉对炎症刺激做出充分反应，这种炎症刺激会导致盆腔区域肌肉适应性缺陷，伴有收缩性改变或痉挛性疼痛性挛缩。它还会由于高强度磁波对细胞膜和细胞质，尤其是对肥大细胞的作用而刺激一系列再生现象，肥大细胞似乎在盆腔区域疼痛的产生中起重要作用。用于治疗皮肤损伤的磁场与AIMED方案的其他操作方法循环应用，在50名患者的治疗组中证实了文献数据。磁场的使用为再生医学开辟了新的前景，因为如果细胞接收到特定信息，它可能会进入自我修复过程。
