Matet Alexandre, Daruich Alejandra, Behar-Cohen Francine
Université de Lausanne, Département d'ophtalmologie, Fondation Asile des aveugles, Hôpital ophtalmique Jules-Gonin, 1011 Lausanne.
INSERM UMR 1138, Université Paris Descartes, Centre de Recherche des Cordeliers, 15, rue de l'Ecole de médecine, 75006 Paris, France.
Rev Med Suisse. 2017 Jan 11;13(544-545):84-87.
Precision medicine is the future. In all fields of medicine, optimized therapy aims at identifying individuals at risks in order to prevent diseases, to identify specific molecular targets in a specific patient, at a specific time, to administer optimized treatment with less side effects. To achieve this ambitious aim, biomarkers, which should be specific and sensitive predictive indicators of diseases, or of response to treatment or of a state of evolution of the disease, must be identified. The eye offers an easy access organ to collect directly media or tissue, which can serve to identify such markers. This paper summarizes recent advances in the identification of ocular biomarkers of ocular diseases but also of brain diseases.
精准医学是未来的发展方向。在医学的各个领域，优化治疗旨在识别有患病风险的个体以预防疾病，在特定时间针对特定患者识别特定分子靶点，从而进行副作用更小的优化治疗。为实现这一宏伟目标，必须识别生物标志物，它们应是疾病、对治疗的反应或疾病进展状态的特异性和敏感性预测指标。眼睛是一个易于直接采集介质或组织的器官，这些介质或组织可用于识别此类标志物。本文总结了在眼部疾病以及脑部疾病的眼部生物标志物识别方面的最新进展。
