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爱尔兰共和国儿童 2 型糖尿病的流行情况和特征。

Prevalence and characteristics of paediatric Type 2 diabetes in the Republic of Ireland.

机构信息

Department of Paediatrics, Midland Regional Hospital, Mullingar, Co, Westmeath.

Department of Paediatrics and Child Health, Cork University Hospital, Wilton, Cork, Ireland.

出版信息

Diabet Med. 2017 Nov;34(11):1603-1607. doi: 10.1111/dme.13425. Epub 2017 Aug 3.

Abstract

OBJECTIVE

To establish the prevalence of paediatric Type 2 diabetes in the Republic of Ireland and describe patient demographics, initial presentation, management, outcomes, comorbidities and complications.

METHODS

Using a standardized proforma we conducted a cross-sectional survey of children and adolescents aged < 16 years with a diagnosis of Type 2 diabetes between October and December 2015 in each of the 19 centres in the Republic of Ireland responsible for the care of children with diabetes.

RESULTS

Twelve cases of Type 2 diabetes were identified, giving a prevalence in children aged <16 years of 1.2/100 000 (95% CI 0.6 to 2). Six of these children (50%) were white, two (33%) of whom were members of the travelling community. Four (33%) were of black ethnicity. The prevalence of Type 2 diabetes in traveller children was 16.1/100 000 (95% CI 1.9 to 58.1) and was similar to that in black children, a known high-risk group, which was 13.3/100 000 (95% CI 3.6 to 34.1). The median current HbA value was 51 mmol/mol (6.8%) and four (33%) of the children achieved the International Society for Pediatric and Adolescent Diabetes target HbA of ≤48 mmol/mol (6.5%). Seven (59%) children were managed on metformin monotherapy, three (25%) were managed on insulin and metformin in combination, and two (16%) were receiving dietary management.

CONCLUSION

This was the first national study to estimate the prevalence of childhood Type 2 diabetes in Ireland. Despite their white ethnicity, traveller children appear to be a high-risk group, but this finding requires further study.

摘要

目的

在爱尔兰共和国确定儿童 2 型糖尿病的流行情况,并描述患者人口统计学特征、初始表现、治疗、结局、合并症和并发症。

方法

我们使用标准化表格,对 2015 年 10 月至 12 月期间在爱尔兰共和国负责儿童糖尿病护理的 19 个中心诊断为 2 型糖尿病的年龄<16 岁的儿童和青少年进行了横断面调查。

结果

确定了 12 例 2 型糖尿病病例,<16 岁儿童的患病率为 1.2/100000(95%CI 0.6 至 2)。其中 6 例(50%)为白人,2 例(33%)为流动社区成员。4 例(33%)为黑人。流动儿童 2 型糖尿病的患病率为 16.1/100000(95%CI 1.9 至 58.1),与已知的高危人群黑人儿童的患病率相似,为 13.3/100000(95%CI 3.6 至 34.1)。目前的中位 HbA 值为 51 mmol/mol(6.8%),4 例(33%)儿童达到国际儿童青少年糖尿病协会的目标 HbA 值≤48 mmol/mol(6.5%)。7 例(59%)儿童接受二甲双胍单药治疗,3 例(25%)儿童接受胰岛素和二甲双胍联合治疗,2 例(16%)儿童接受饮食管理。

结论

这是首次在爱尔兰全国范围内估计儿童 2 型糖尿病的患病率。尽管他们的种族是白人,但流动儿童似乎是一个高危人群,但这一发现需要进一步研究。

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