a Department of Zoology , University of Calcutta , Kolkata , India.
Arch Physiol Biochem. 2018 Feb;124(1):18-26. doi: 10.1080/13813455.2017.1352605. Epub 2017 Jul 13.
Millions of people consume betel nut for increased capacity to work and for stress reduction. The nut contains arecoline, which has multiple side effects on endocrine functions. Objective of the work is to investigate pineal-testicular responses to noise and after arecoline treatment in noise in rats. Noise exposure (100 dB, 6 h daily, 10 days) caused pineal stimulation ultrastructurally and at indoleamines level. Leydig cell dysfunction with fall of testosterone level and suppression of sex accessories were noticed. In contrast, pineal activity was inhibited and reproductive functions were stimulated after arecoline administration, confirmed from reversed changes to those of noise. Arecoline treatment in noise exposure showed same results as in noise both in pineal and in reproductive functions. It is concluded that noise causes testicular dysfunction probably by gonadotropin suppression induced by pineal melatonin in noise. Furthermore, arecoline cannot prevent it in noise in rats.
数百万人食用槟榔以提高工作能力和减轻压力。这种坚果含有槟榔碱，它对内分泌功能有多种副作用。这项工作的目的是研究松果腺-睾丸对噪声和噪声后槟榔碱处理的反应在大鼠中。噪声暴露（100dB，每天 6 小时，10 天）导致松果腺超微结构和吲哚胺水平的刺激。发现睾丸间质细胞功能障碍，睾丸酮水平下降，性附属物受到抑制。相比之下，槟榔碱给药后，松果腺活性受到抑制，生殖功能受到刺激，这从与噪声相反的变化得到证实。在噪声暴露中，槟榔碱处理与噪声一样，对松果腺和生殖功能都有相同的影响。研究结果表明，噪声可能通过松果腺褪黑素抑制促性腺激素，导致睾丸功能障碍。此外，在噪声中，槟榔碱不能预防这种情况。
