a Department of Clinical Biochemistry, School of Medicine , Hamadan University of Medical Sciences , Hamadan , Iran.
b Neurophysiology Research Center , Hamadan University of Medical Sciences , Hamadan , Iran.
Crit Rev Clin Lab Sci. 2017 Jun;54(4):267-293. doi: 10.1080/10408363.2017.1343274. Epub 2017 Jul 13.
Resveratrol (RES), a well-known antioxidant, is present in numerous plant species and, as a result, is easily obtained through dietary intake of plant-based foods and beverages. Several studies suggest that RES has anti-carcinogenic, anti-microbial, and anti-viral effects. It may also have beneficial metabolic properties that result in mitigation of insulin resistance (IR) and related metabolic abnormalities, including dyslipidemia, hyperglycemia, and hyperinsulinemia through regulation of gene expression or the activity of rate-limiting enzymes. A large body of evidence supports the beneficial effects of RES in the management and treatment of IR, type 2 diabetes, and related complications through a multitude of mechanisms. This review article focuses on the mechanisms of action of RES, the mechanisms leading to improved insulin sensitivity, and its clinical role in the management and treatment of type 2 diabetes.
白藜芦醇（RES）是一种众所周知的抗氧化剂，存在于许多植物物种中，因此可以通过食用植物性食物和饮料轻松获得。多项研究表明，RES 具有抗癌、抗菌和抗病毒作用。它还可能具有有益的代谢特性，通过调节基因表达或限速酶的活性，减轻胰岛素抵抗（IR）和相关代谢异常，包括血脂异常、高血糖和高胰岛素血症。大量证据支持 RES 通过多种机制在管理和治疗 IR、2 型糖尿病及其相关并发症方面的有益作用。本文重点介绍 RES 的作用机制、导致胰岛素敏感性改善的机制及其在 2 型糖尿病管理和治疗中的临床作用。
