石竹烷硫醇、乙烯基硫醚、二硫化物和双硫化物：抗氧化和膜保护活性。

Caryophyllane Thiols, Vinyl Thioethers, Di- and Bis-Sulfides: Antioxidant and Membrane Protective Activities.

作者信息

Gyrdymova Yulia V, Sudarikov Denis V, Shevchenko Oksana G, Rubtsova Svetlana A, Slepukhin Pavel A, Kutchin Aleksandr V

机构信息

Institute of Chemistry of the Komi Science Center, Ural Branch of the Russian Academy of Sciences, 48, Pervomaiskaya Ul., Syktyvkar, 167000, Russia.

Institute of Biology of the Komi Science Center, Ural Branch of the Russian Academy of Sciences, 28, Kommunisticheskaya Ul., Syktyvkar, 167000, Russia.

出版信息

Chem Biodivers. 2017 Dec;14(12). doi: 10.1002/cbdv.201700296. Epub 2017 Dec 5.

DOI:10.1002/cbdv.201700296

PMID:28704572

Abstract

Caryophyllane thioterpenoids were synthesized in 23 - 81% yields. The antioxidant properties of the obtained compounds in various model systems were found. It was revealed that 4,5-epoxycaryophyll-9-ylmethanethiol has the greatest antioxidant activity. The isomerism of sesquiterpenic fragments was shown to have a significant effect on the biological activity of the compounds.

摘要

石竹烷硫代萜类化合物的合成产率为23% - 81%。研究了所得化合物在各种模型体系中的抗氧化性能。结果表明，4,5-环氧石竹-9-基甲硫醇具有最大的抗氧化活性。倍半萜片段的异构现象对化合物的生物活性有显著影响。