不对称单萜基杂芳基二硫醚的合成及生物活性。
Synthesis and Biological Activity of Unsymmetrical Monoterpenylhetaryl Disulfides.
机构信息
Institute of Chemistry, FRC "Komi Scientific Centre", Ural Branch of the Russian Academy of Sciences, Pervomayskaya St. 48, 167000 Syktyvkar, Komi Republic, Russia.
Department of Chemistry, Nizhny Novgorod State Technical University n.a. R.E. Alekseev, 24 Minin St., 603155 Nizhny Novgorod, Russia.
出版信息
Molecules. 2022 Aug 10;27(16):5101. doi: 10.3390/molecules27165101.
New unsymmetrical monoterpenylhetaryl disulfides based on heterocyclic disulfides and monoterpene thiols were synthesized for the first time in 48-88% yields. Hydrolysis of disulfides with fragments of methyl esters of 2-mercaptonicotinic acid was carried out in 73-95% yields. The obtained compounds were evaluated for antioxidant, antibacterial, antifungal activity, cytotoxicity and mutagenicity.
首次以 48-88%的收率合成了基于杂环二硫化物和单萜硫醇的新型非对称单萜杂芳基二硫化物。二硫化物的水解与 2-巯基烟酰基甲酯的片段以 73-95%的收率进行。对所得到的化合物进行了抗氧化、抗菌、抗真菌活性、细胞毒性和致突变性评价。
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