Kubo Kazuki, Monzen Hajime, Ishii Kentaro, Tamura Mikoto, Kawamorita Ryu, Sumida Iori, Mizuno Hirokazu, Nishimura Yasumasa
Department of Medical Physics, Graduate School of Medical Sciences, Kindai University, 377-2 Ohno-higashi, Osakasayama, Osaka 589-8511, Japan; Department of Radiation Oncology, Tane General Hospital, 1-12-21 Kujo-minami, Nishi-ku, Osaka 550-0025, Japan.
Department of Medical Physics, Graduate School of Medical Sciences, Kindai University, 377-2 Ohno-higashi, Osakasayama, Osaka 589-8511, Japan.
Phys Med. 2017 Dec;44:199-204. doi: 10.1016/j.ejmp.2017.06.026. Epub 2017 Jul 10.
This study evaluated whether RapidPlan based plans (RP plans) created by a single optimization, are usable in volumetric modulated arc therapy (VMAT) for patients with prostate cancer.
We used 51 previously administered VMAT plans to train a RP model. Thirty RP plans were created by a single optimization without planner intervention during optimization. Differences between RP plans and clinical manual optimization (CMO) plans created by an experienced planner for the same patients were analyzed (Wilcoxon tests) in terms of homogeneity index (HI), conformation number (CN), D, and D to planning target volume (PTV), mean dose, V, V, V, and V to rectum and bladder, monitor unit (MU), and multi-leaf collimator (MLC) sequence complexity.
RP and CMO values for PTV D, PTV D, HI, and CN were significantly similar (p<0.05 for all). RP mean dose, V, and V to rectum were superior or comparable to CMO values; RP V and V were higher than in CMO plans (p<0.05). RP bladder dose-volume parameter values (except V) were lower than in CMO plans (p<0.05). MU values were RP: 730±55MU and CMO: 580±37MU (p<0.05); and MLC sequence complexity scores were RP: 0.25±0.02 and CMO: 0.35±0.03 (p<0.05).
RP plans created by a single optimization were clinically acceptable in VMAT for patient with prostate cancer. Our simple model could reduce optimization time, independently of planner's skill and knowledge.
本研究评估了通过单次优化创建的基于快速计划（RP计划）是否可用于前列腺癌患者的容积调强弧形放疗（VMAT）。
我们使用51个先前实施的VMAT计划来训练一个RP模型。在优化过程中，通过单次优化创建了30个RP计划，且没有计划者干预。分析了RP计划与由经验丰富的计划者为相同患者创建的临床手动优化（CMO）计划之间在均匀性指数（HI）、适形数（CN）、D以及到计划靶体积（PTV）的D、平均剂量、V、V、V和V到直肠和膀胱、监测单位（MU）以及多叶准直器（MLC）序列复杂性方面的差异（Wilcoxon检验）。
PTV D、PTV D、HI和CN的RP值与CMO值显著相似（所有p<0.05）。RP到直肠的平均剂量、V和V优于或与CMO值相当；RP的V和V高于CMO计划（p<0.05）。RP膀胱剂量体积参数值（V除外）低于CMO计划（p<0.05）。MU值为RP：730±55MU，CMO：580±37MU（p<0.05）；MLC序列复杂性评分分别为RP：0.25±0.02，CMO：0.35±0.03（p<0.05）。
通过单次优化创建的RP计划在VMAT中对于前列腺癌患者在临床上是可接受的。我们的简单模型可以减少优化时间，且与计划者的技能和知识无关。
