Fuentes Francisco, Palomo Iván, Fuentes Eduardo
Becario Obstetricia y Ginecología Universidad Católica del Maule, Talca, Chile.
Platelet Research Center, Department of Clinical Biochemistry and Immunohaematology, Faculty of Health Sciences, Interdisciplinary Excellence Research Program on Healthy Aging (PIEI-ES), Universidad de Talca, Talca, Chile.
Vascul Pharmacol. 2017 Aug;93-95:14-19. doi: 10.1016/j.vph.2017.07.003. Epub 2017 Jul 11.
The average lifespan of humans and the percentage of people entering the 65 and older age group are growing rapidly. Within this age group, cardiovascular diseases (CVD) increase steeply and are the most common cause of death. During aging, experimental and clinical studies support the pivotal role played by reactive oxidant species in the mechanism of platelet activation. Frailty has been implicated as a causative and prognostic factor in patients with CVD. Oxidative stress is increased in frail older people, and may lead to accelerated aging and higher incidence of oxidative diseases such as CVD. The present article aims to highlight the relative contribution of platelet oxidative stress as a key target of frailty in elderly people with CVD.
人类的平均寿命以及进入65岁及以上年龄组的人口百分比正在迅速增长。在这个年龄组中，心血管疾病（CVD）急剧增加，是最常见的死亡原因。在衰老过程中，实验和临床研究支持活性氧物种在血小板激活机制中发挥的关键作用。虚弱被认为是心血管疾病患者的一个致病和预后因素。体弱的老年人氧化应激增加，可能导致加速衰老和氧化疾病（如心血管疾病）的更高发病率。本文旨在强调血小板氧化应激作为老年心血管疾病患者虚弱的关键靶点的相对作用。
