Zhang Shouyao, Xia Bo, Kalionis Bill, Li Huan, Zhang Xinyan, Zhang Xinghe, Xia Shijin
The Second Clinical Medical College, The Second Affiliated Hospital, Yunnan University of Chinese Medicine, Kunming, China.
Master of Science in Computer Science, Sofia University, Palo Alto, CA, USA.
Aging Dis. 2024 Sep 1. doi: 10.14336/AD.2024.0717.
Vascular aging is the pathological basis for the aging of various organ systems in the human body and is a common pathogenesis leading to the development of atherosclerosis, Alzheimer's disease, and other conditions among older adults. Aging is characterized by accelerated pulse wave velocity, thickening of the carotid artery intima-media, and decreased vascular dilation function. Signaling pathways such as mTOR, AMPK, NF-κB, Klotho, SIRT, and other key proteins are likely involved in these processes. The detection of biomarkers related to vascular aging, including senescence-associated β-galactosidase, endothelial progenitor cells, circulating endothelial microparticles, and exosomal miRNAs, aids in assessing vascular status and prognosis. Repairing endothelial injury, reducing oxidative stress-inflammatory responses, and restoring mitochondrial and telomere functions are reliable measures to counter vascular aging. In summary, research on vascular aging is the driving force that will provide rational strategies to intervene in geriatric vascular diseases and achieve the long-term goal of healthy aging.
血管老化是人体各器官系统老化的病理基础，是导致老年人动脉粥样硬化、阿尔茨海默病等疾病发生发展的常见发病机制。衰老的特征是脉搏波速度加快、颈动脉内膜中层增厚以及血管舒张功能下降。mTOR、AMPK、NF-κB、Klotho、SIRT等信号通路以及其他关键蛋白可能参与这些过程。检测与血管老化相关的生物标志物，包括衰老相关β-半乳糖苷酶、内皮祖细胞、循环内皮微粒和外泌体miRNA，有助于评估血管状态和预后。修复内皮损伤、减轻氧化应激-炎症反应以及恢复线粒体和端粒功能是对抗血管老化的可靠措施。总之，血管老化研究是为干预老年血管疾病提供合理策略并实现健康老龄化长期目标的驱动力。
