在艾滋病相关的持续性全身性淋巴结病中，次级淋巴滤泡的损伤，这是由具有免疫反应性酸性半胱氨酸蛋白酶抑制剂的树突状网状细胞的行为所揭示的。

Damage to secondary lymphoid follicles in AIDS-related persistent generalized lymphadenopathy, as revealed by the behaviour of dendritic reticulum cells possessing immunoreactive acid cysteine-proteinase inhibitor.

作者信息

Alavaikko M, Rinne A, Järvinen M, Hopsu-Havu V K, Aine R, Levine A M, Meyer P R, Lukes R J

出版信息

Virchows Arch B Cell Pathol Incl Mol Pathol. 1986;50(4):299-311. doi: 10.1007/BF02889909.

Abstract

It has been shown previously that dendritic reticulum cells (DRC) in human secondary lymphoid follicles possess an immunoreactive acid cysteine-proteinase inhibitor (ACPI). In the present study, lymph nodes from 12 patients with AIDS-related persistent generalized lymphadenopathy (PGL) were investigated in order to detect whether or not any alterations occur in ACPI-immunoreactive DRC in this disorder. In the majority of PGL cases, profound alterations were found, the main characteristics of which were erosion, partial or total disruption of lymphoid follicles. However, similar though much less marked alterations were also found in some control cases. It is concluded that this type of follicular damage is a common and characteristic feature in PGL. It is not specific to PGL, however, but represents rather a special type of reaction in lymphatic tissue. The advantage of ACPI immunohistology for demonstrating the DRC pattern is that it can be performed on routinely fixed and paraffin-embedded tissues.

摘要

先前的研究表明，人类次级淋巴滤泡中的树突状网状细胞（DRC）具有免疫反应性酸性半胱氨酸蛋白酶抑制剂（ACPI）。在本研究中，对12例艾滋病相关持续性全身性淋巴结病（PGL）患者的淋巴结进行了调查，以检测该疾病中ACPI免疫反应性DRC是否发生任何改变。在大多数PGL病例中，发现了深刻的改变，其主要特征是淋巴滤泡的侵蚀、部分或完全破坏。然而，在一些对照病例中也发现了类似但程度较轻的改变。得出的结论是，这种类型的滤泡损伤是PGL的常见和特征性特征。然而，它并非PGL所特有，而是代表了淋巴组织中的一种特殊反应类型。ACPI免疫组织化学用于显示DRC模式的优点是它可以在常规固定和石蜡包埋的组织上进行。