Mortier E, Versichelen L, Herregods L, Rolly G
Acta Anaesthesiol Belg. 1987;38(1):83-7.
Vecuronium (V) and atracurium (A) were compared in a randomised study in premedicated patients undergoing laparoscopy for gynecological pathology. Both groups contained ten patients. Anesthesia was induced with fentanyl (0.1 mg) and thiopentone (1 mg/kg initially and subsequently 4 mg/kg). A priming dose of vecuronium (20 micrograms/kg) or atracurium (100 micrograms/kg) was given one minute before the intubating dose (60 micrograms/kg for vecuronium and 300 micrograms/kg for atracurium). Ninety seconds thereafter intubation was performed. Maintenance of anesthesia consisted of isoflurane at an inspiratory concentration of 1% in a mixture of O2/N2O (50%/50%) with small supplements of fentanyl. Neuromuscular block was monitored with the Datex Relaxograph. Results show that neither drug offers major clinical advantages over the other: there is no difference in speed of onset (V:T190sec 14.6 +/- 4.3%; A:T190sec 23.5 +/- 6.5%; Mean +/- SEM) and duration of neuromuscular block (V:T150sec 34.2 +/- 3.5 min; A:T150sec 41.3 +/- 2.8 min; Mean +/- SEM) and intubation conditions are almost identical.
在一项随机研究中，对接受妇科病理腹腔镜检查的经术前用药的患者比较了维库溴铵（V）和阿曲库铵（A）。两组各有10名患者。用芬太尼（0.1毫克）和硫喷妥钠（初始剂量1毫克/千克，随后4毫克/千克）诱导麻醉。在插管剂量（维库溴铵60微克/千克，阿曲库铵300微克/千克）前1分钟给予维库溴铵（20微克/千克）或阿曲库铵（100微克/千克）的预充剂量。此后90秒进行插管。麻醉维持采用异氟烷，在O2/N2O（50%/50%）混合气体中吸入浓度为1%，并小剂量补充芬太尼。用Datex Relaxograph监测神经肌肉阻滞。结果显示，两种药物在临床上均未显示出相对于另一种药物的主要优势：起效速度（V：T190秒时14.6±4.3%；A：T190秒时23.5±6.5%；平均值±标准误）和神经肌肉阻滞持续时间（V：T150秒时34.2±3.5分钟；A：T150秒时41.3±2.8分钟；平均值±标准误）无差异，插管条件几乎相同。
