Sasaki H, Muramoto O, Kanazawa I, Arai H, Kosaka K, Iizuka R
Ann Neurol. 1986 Mar;19(3):263-9. doi: 10.1002/ana.410190307.
We measured the concentrations of glutamate, aspartate, and gamma-aminobutyrate (GABA) in cortical and subcortical areas by an enzymatic fluorometric method in 9 patients with histologically verified Alzheimer's disease and senile dementia of the Alzheimer type (AD/SDAT), and in 10 age-matched normal control subjects. When compared with controls, the concentration of glutamate in cortical and subcortical areas of AD/SDAT brains was significantly reduced. The concentrations of aspartate and GABA were also reduced in several areas, but the magnitude of reduction was less than that of glutamate. This apparent reduction of glutamate in postmortem brains might have a bearing on pathophysiological mechanisms in AD/SDAT.
我们采用酶荧光法，对9例经组织学证实的阿尔茨海默病及阿尔茨海默型老年性痴呆（AD/SDAT）患者以及10名年龄匹配的正常对照者的皮质和皮质下区域的谷氨酸、天冬氨酸和γ-氨基丁酸（GABA）浓度进行了测量。与对照组相比，AD/SDAT患者大脑皮质和皮质下区域的谷氨酸浓度显著降低。天冬氨酸和GABA的浓度在几个区域也有所降低，但降低幅度小于谷氨酸。死后大脑中谷氨酸的这种明显减少可能与AD/SDAT的病理生理机制有关。
