阿尔茨海默病患者颞叶新皮质活检样本中的氨基酸释放情况。

Amino acid release from biopsy samples of temporal neocortex from patients with Alzheimer's disease.

作者信息

Smith C C, Bowen D M, Sims N R, Neary D, Davison A N

出版信息

Brain Res. 1983 Mar 28;264(1):138-41. doi: 10.1016/0006-8993(83)91131-9.

Abstract

Tissue prisms prepared from neurosurgical samples of temporal neocortex of Alzheimer and control patients, upon depolarization preferentially released aspartate, glutamate and gamma-aminobutyrate (GABA). The Alzheimer and control samples did not significantly differ in the pattern of amino acid release, although acetylcholine synthesis by the Alzheimer tissue prisms was greatly reduced. There was no correlation between the efflux of any amino and acetylcholine synthesis. These observations suggest that in Alzheimer's disease there are no major changes in the extracellular concentrations of these putative amino acid transmitters.

摘要

从阿尔茨海默病患者和对照患者颞叶新皮质的神经外科样本制备的组织棱镜，在去极化时优先释放天冬氨酸、谷氨酸和γ-氨基丁酸（GABA）。尽管阿尔茨海默病组织棱镜的乙酰胆碱合成大大减少，但阿尔茨海默病样本和对照样本在氨基酸释放模式上没有显著差异。任何氨基酸的流出与乙酰胆碱合成之间没有相关性。这些观察结果表明，在阿尔茨海默病中，这些假定的氨基酸递质的细胞外浓度没有重大变化。