Li Hong, Yu Shasha, Wang Rui, Sun Zhaoqing, Zhou Xinghu, Zheng Liqiang, Yin Zhihua, Zhang Xingang, Sun Yingxian
Department of Cardiology, Shengjing Hospital of China Medical University, 36 Sanhao Street, Shenyang 110004, China.
Department of Cardiology, The First Hospital of China Medical University, 155 North Nanjing Street, Shenyang 110001, China.
Biomed Res Int. 2017;2017:6594271. doi: 10.1155/2017/6594271. Epub 2017 Jun 19.
Ischemic stroke is a complex disorder resulting from the interplay of genetic and environmental factors. Previous studies showed that kalirin gene variations were associated with cardiovascular disease. However, the association between this gene and ischemic stroke was unknown. We performed this study to confirm if kalirin gene variation was associated with ischemic stroke.
We enrolled 385 ischemic stroke patients and 362 controls from China. Three SNPs of kalirin gene were genotyped by means of ligase detection reaction-PCR method. Data was processed with SPSS and SHEsis platform.
SNP rs7620580 (dominant model: OR = 1.590, = 0.002 and adjusted OR = 1.662, = 0.014; additive model: OR = 1.490, = 0.002 and adjusted OR = 1.636, = 0.005; recessive model: OR = 2.686, = 0.039) and SNP rs1708303 (dominant model: OR = 1.523, = 0.007 and adjusted OR = 1.604, = 0.028; additive model: OR = 1.438, = 0.01 and adjusted OR = 1.476, = 0.039) were associated with ischemic stroke. The GG genotype and G allele of SNP rs7620580 were associated with a risk for ischemic stroke with an adjusted OR of 3.195 and an OR of 1.446, respectively. Haplotype analysis revealed that A-T-G,G-T-A, and A-T-A haplotypes were associated with ischemic stroke.
Our results provide evidence that kalirin gene variations were associated with ischemic stroke in the Chinese Han population.
缺血性中风是一种由遗传和环境因素相互作用导致的复杂疾病。先前的研究表明，卡里林基因变异与心血管疾病有关。然而，该基因与缺血性中风之间的关联尚不清楚。我们开展这项研究以确认卡里林基因变异是否与缺血性中风有关。
我们从中国招募了385例缺血性中风患者和362例对照。采用连接酶检测反应 - 聚合酶链反应方法对卡里林基因的三个单核苷酸多态性（SNP）进行基因分型。数据使用SPSS和SHEsis平台进行处理。
SNP rs7620580（显性模型：比值比（OR）= 1.590，P = 0.002，校正OR = 1.662，P = 0.014；加性模型：OR = 1.490，P = 0.002，校正OR = 1.636，P = 0.005；隐性模型：OR = 2.686，P = 0.039）和SNP rs1708303（显性模型：OR = 1.523，P = 0.007，校正OR = 1.604，P = 0.028；加性模型：OR = 1.438，P = 0.01，校正OR = 1.476，P = 0.039）与缺血性中风有关。SNP rs7620580的GG基因型和G等位基因分别与缺血性中风风险相关，校正OR为3.195，OR为1.446。单倍型分析显示，A - T - G、G - T - A和A - T - A单倍型与缺血性中风有关。
我们的结果提供了证据，表明卡里林基因变异与中国汉族人群的缺血性中风有关。
