Thuraisingham R A
, 1A, Russell St, Eastwood, NSW, 2122, Australia.
J Mol Neurosci. 2017 Aug;62(3-4):363-367. doi: 10.1007/s12031-017-0946-5. Epub 2017 Jul 13.
The Puri-Li kinetic model is explored here to study the contribution of microglia and astroglia during the pathogenesis of Alzheimer's disease (AD). This is carried out by solving the Puri-Li model under steady-state conditions. The derived expressions show that both of them play a role in the pathogenesis of AD. Examination of the steady-state solutions where microglia and astroglia are involved shows that equilibrium conditions are achieved by microglia and astroglia destroying neurons. These findings from this model are in agreement with the results in the literature, where microglia and astroglia are considered to act as inflammatory cells producing toxins to destroy neurons. In addition, the study also showed that the number ratio of the total astroglial cells to the total microglial cells increases with the progression of AD. With advances in three dimensional imaging and selective staining, this ratio could be used as a valuable marker to monitor AD.
本文探讨了普里-李动力学模型，以研究小胶质细胞和星形胶质细胞在阿尔茨海默病（AD）发病机制中的作用。这是通过在稳态条件下求解普里-李模型来实现的。推导得出的表达式表明，它们两者在AD的发病机制中都起作用。对涉及小胶质细胞和星形胶质细胞的稳态解的研究表明，小胶质细胞和星形胶质细胞通过破坏神经元来达到平衡状态。该模型的这些发现与文献中的结果一致，在文献中，小胶质细胞和星形胶质细胞被认为是产生毒素破坏神经元的炎性细胞。此外，研究还表明，随着AD的进展，星形胶质细胞总数与小胶质细胞总数的数量比会增加。随着三维成像和选择性染色技术的进步，该比例可作为监测AD的一个有价值的标志物。
