Nieto-Sampedro M, Mora F
Department of Neural Plasticity, Instituto Cajal, C.S.I.C., Madrid, Spain.
Neuroreport. 1994 Jan 12;5(4):375-80. doi: 10.1097/00001756-199401120-00001.
We propose that Alzheimer's disease is initiated by failure of axonal transport. After the neurodegeneration cascade is initiated, microglial and astroglial cells have major roles in directly and indirectly promoting self-sustaining neurodegeneration cycles. This hypothesis makes testable predictions and suggests logical therapies.
我们提出，阿尔茨海默病是由轴突运输功能障碍引发的。在神经退行性变级联反应启动后，小胶质细胞和星形胶质细胞在直接和间接促进自我持续的神经退行性变循环中起主要作用。这一假说做出了可检验的预测，并提出了合理的治疗方法。
