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兴奋性氨基酸拮抗剂 DL-2-氨基-5-磷酸戊酸诱导的苯环己哌啶样僵住症。

Phencyclidine-like catalepsy induced by the excitatory amino acid antagonist DL-2-amino-5-phosphonovalerate.

作者信息

Koek W, Kleer E, Mudar P J, Woods J H

出版信息

Behav Brain Res. 1986 Mar;19(3):257-9. doi: 10.1016/0166-4328(86)90026-4.

DOI:10.1016/0166-4328(86)90026-4
PMID:2870725
Abstract

This study presents experimental evidence for the mediation of a behavioral effect of phencyclidine-like drugs by inhibition of neurotransmission at excitatory synapses utilizing N-methyl-aspartate (NMA) receptors by showing that DL-2-amino-5-phosphonovalerate, a selective NMA antagonist, produces phencyclidine-like catalepsy in pigeons. This finding suggests the possibility that other behavioral actions of phencyclidine-like substances may be mediated in a similar fashion.

摘要

本研究通过表明选择性N-甲基-D-天冬氨酸（NMA）拮抗剂DL-2-氨基-5-磷酸戊酸在鸽子中产生苯环利定样僵住症，为通过抑制利用NMA受体的兴奋性突触处的神经传递来介导苯环利定样药物的行为效应提供了实验证据。这一发现表明，苯环利定样物质的其他行为作用可能以类似方式介导。

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Phencyclidine-like catalepsy induced by the excitatory amino acid antagonist DL-2-amino-5-phosphonovalerate.兴奋性氨基酸拮抗剂 DL-2-氨基-5-磷酸戊酸诱导的苯环己哌啶样僵住症。
Behav Brain Res. 1986 Mar;19(3):257-9. doi: 10.1016/0166-4328(86)90026-4.
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引用本文的文献

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Discriminative stimulus effects of a centrally administered, delta-opioid peptide (D-Pen2-D-Pen5-enkephalin) in pigeons.中枢给予的δ-阿片肽（D-青霉胺2-D-青霉胺5-脑啡肽）对鸽子的辨别性刺激作用。
Psychopharmacology (Berl). 1996 Oct;127(3):225-30.
2
Response repetition in pigeons: pharmacological and behavioral specificity.
Psychopharmacology (Berl). 1986;90(4):475-81. doi: 10.1007/BF00174064.
3
Effects of phencyclidine, SKF 10,047 and related psychotomimetic agents on N-methyl-D-aspartate receptor mediated synaptic responses in rat hippocampal slices.苯环利定、SKF 10047及相关拟精神病药物对大鼠海马脑片N-甲基-D-天冬氨酸受体介导的突触反应的影响。
Br J Pharmacol. 1987 Jul;91(3):547-56. doi: 10.1111/j.1476-5381.1987.tb11248.x.
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Is the discriminative stimulus produced by phencyclidine due to an interaction with N-methyl-D-aspartate receptors?苯环利定产生的辨别性刺激是由于与N-甲基-D-天冬氨酸受体相互作用所致吗？
Psychopharmacology (Berl). 1988;96(1):87-92. doi: 10.1007/BF02431538.
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Phencyclidine (PCP)-like discriminative stimulus effects of metaphit and of 2-amino-5-phosphonovalerate in pigeons: generality across different training doses of PCP.
Psychopharmacology (Berl). 1987;93(4):437-42. doi: 10.1007/BF00207232.
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Phencyclidine. Physiological actions, interactions with excitatory amino acids and endogenous ligands.苯环利定。生理作用、与兴奋性氨基酸及内源性配体的相互作用。
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