N-甲基-D-天冬氨酸受体拮抗剂对大鼠学习能力的损害
Learning impairment in rats by N-methyl-D-aspartate receptor antagonists.
作者信息
Danysz W, Wroblewski J T, Costa E
机构信息
Fidia-Georgetown Institute for the Neurosciences, Georgetown University School of Medicine, Washington, D.C. 20007.
出版信息
Neuropharmacology. 1988 Jun;27(6):653-6. doi: 10.1016/0028-3908(88)90189-x.
PMID:2901678
Abstract
2-Amino-5-phosphonovalerate (APV, icv) phencyclidine (PCP, ip) and scopolamine (sc) dose-dependently disrupted short term working memory in radial maze. These drugs injected before, but not after training attenuated retention of long term memory in passive avoidance task. A relation of PCP action to its antagonism at NMDA receptors may be suggested.
摘要
2-氨基-5-磷酸戊酸（APV，脑室内注射）、苯环己哌啶（PCP，腹腔注射）和东莨菪碱（sc）剂量依赖性地破坏放射状迷宫中的短期工作记忆。这些药物在训练前而非训练后注射会减弱被动回避任务中的长期记忆保持。这可能提示了PCP的作用与其对N-甲基-D-天冬氨酸（NMDA）受体的拮抗作用之间的关系。
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