银杏叶提取物在血管保护中的作用：分子机制与临床应用。
Ginkgo biloba Extract in Vascular Protection: Molecular Mechanisms and Clinical Applications.
机构信息
Cardiovascular Disease Centre, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing. China.
Cardiovascular Disease Centre, Xiyuan Hospital, China Academy of Chinese Medical Sciences, P.O. Box: 100091, Beijing. China.
出版信息
Curr Vasc Pharmacol. 2017;15(6):532-548. doi: 10.2174/1570161115666170713095545.
BACKGROUND
Leaves of Ginkgo biloba, a "living fossil," have been used as traditional herbal medicine for hundreds of years in China. Currently, its application in vascular protection is garnering much attention.
METHODS
In this manuscript, preclinical studies were reviewed to discuss various mechanisms underlying the vascular protection by Ginkgo biloba extract (GBE). Additionally, we reviewed clinical studies to present the application of GBE in the ischaemic disease.
RESULTS
GBE, a commonly used dietary supplement, has been shown to act as an antioxidant and freeradical scavenger, a membrane stabilizer, an inhibitor of the platelet-activating factor, a vasodilator, and a regulator of metabolism. Currently, there exist a growing number of clinical studies about GBE in the application of cardiovascular disease, peripheral vascular disease (PVD) and diabetic vascular complications.
CONCLUSION
GBE, a promising therapeutic agent for cardiovascular and ischaemic diseases, exerts vascular- protection function by a comprehensive mechanisms.
背景
银杏叶是一种“活化石”，在中国已被用作传统草药数百年。目前，其在血管保护方面的应用备受关注。
方法
本文综述了银杏叶提取物（GBE）的血管保护作用的各种机制的临床前研究。此外，我们还回顾了银杏叶提取物在缺血性疾病中的应用的临床研究。
结果
GBE 是一种常用的膳食补充剂，已被证明具有抗氧化和自由基清除作用、膜稳定剂、血小板激活因子抑制剂、血管扩张剂和代谢调节剂的作用。目前，有越来越多的关于银杏叶提取物在心血管疾病、周围血管疾病（PVD）和糖尿病血管并发症应用的临床研究。
结论
银杏叶提取物是一种有前途的心血管和缺血性疾病治疗药物，通过多种机制发挥血管保护作用。
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