根据感染SIVmac239的北豚尾猴（Macaca leonina）的T细胞表型预测疾病进展。
Predict disease progression from T-cell phenotypes in northern pig-tailed macaques (Macaca leonina) during SIVmac239 infection.
作者信息
Zhang Ming-Xu, Zheng Hong-Yi, Jiang Jin, Song Jia-Hao, Chen Min, Xiao Yu, Lian Xiao-Dong, Song Tian-Zhang, Tian Ren-Rong, Pang Wei, Zheng Yong-Tang
机构信息
Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
University of Chinese Academy of Sciences, Beijing, China.
出版信息
Immunology. 2017 Dec;152(4):574-579. doi: 10.1111/imm.12794. Epub 2017 Aug 14.
Abstract
Macaca leonina (northern pig-tailed macaques, NPMs) have variable disease progression during SIVmac239 infection. In the present study, we analysed, for the first time, the correlations between T-cell phenotypes and disease progression in NPMs during SIVmac239 infection. In comparison to normal progressors (NPs), slow progressors (SPs) had lower chronic T-cell activation and exhaustion levels. In addition, SPs showed higher peripheral CD4 T-cell count and CD4 : CD8 ratio, and lower plasma viral load than NPs. CD4 T-cell count and CD4 : CD8 ratio decreased more sharply in NPs than in SPs. Furthermore, T cells in NPs were more highly differentiated, at least in acute infection, than in SPs. These results indicated that T-cell phenotypes were correlated with disease progression in SIVmac239-infected NPMs and these correlations may provide valuable guidance for the improvement of therapeutic strategies tested in NPMs.
摘要
狮尾猕猴（北方豚尾猕猴，NPMs）在感染SIVmac239期间疾病进展情况各异。在本研究中，我们首次分析了NPMs在感染SIVmac239期间T细胞表型与疾病进展之间的相关性。与正常进展者（NPs）相比，缓慢进展者（SPs）的慢性T细胞活化和耗竭水平较低。此外，与NPs相比，SPs的外周血CD4 T细胞计数和CD4∶CD8比值更高，血浆病毒载量更低。NPs的CD4 T细胞计数和CD4∶CD8比值下降幅度比SPs更大。此外，至少在急性感染期，NPs中的T细胞比SPs中的T细胞分化程度更高。这些结果表明，T细胞表型与感染SIVmac239的NPMs的疾病进展相关，这些相关性可能为改进在NPMs中测试的治疗策略提供有价值的指导。
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