Chehimi Marwa, Vidal Hubert, Eljaafari Assia
Univ-Lyon, CarMeN Laboratory, Inserm U1060, INRA U1397, Université Claude Bernard Lyon 1, INSA Lyon, Charles Mérieux Medical School, F-69600 Oullins, France.
Clinical Research Department, Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, F-69495 Pierre Bénite, France.
J Clin Med. 2017 Jul 14;6(7):68. doi: 10.3390/jcm6070068.
Obesity is associated with low-grade chronic inflammation. Indeed, adipose tissues (AT) in obese individuals are the former site of progressive infiltration by pro-inflammatory immune cells, which together with increased inflammatory adipokine secretion induce adipocyte insulin resistance. IL-17-producing T (Th17) cells are part of obese AT infiltrating cells, and are likely to be promoted by adipose tissue-derived mesenchymal stem cells, as previously reported by our team. Whereas Th17 cell are physiologically implicated in the neutralization of fungal and bacterial pathogens through activation of neutrophils, they may also play a pivotal role in the onset and/or progression of chronic inflammatory diseases, or cancer, in which obesity is recognized as a risk factor. In this review, we will highlight the pathogenic role of IL-17A producing cells in the mechanisms leading to inflammation in obesity and to progression of obesity-related inflammatory diseases.
肥胖与低度慢性炎症相关。事实上，肥胖个体的脂肪组织（AT）是促炎免疫细胞进行性浸润的部位，这些免疫细胞与炎症性脂肪因子分泌增加一起诱导脂肪细胞胰岛素抵抗。产生白细胞介素-17的T（Th17）细胞是肥胖脂肪组织浸润细胞的一部分，正如我们团队之前报道的，它们可能由脂肪组织来源的间充质干细胞促进。虽然Th17细胞在生理上通过激活中性粒细胞参与真菌和细菌病原体的中和，但它们也可能在慢性炎症性疾病或癌症的发生和/或进展中起关键作用，而肥胖被认为是这些疾病的一个风险因素。在这篇综述中，我们将强调产生白细胞介素-17A的细胞在导致肥胖炎症和肥胖相关炎症性疾病进展的机制中的致病作用。
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