Department of Neurology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, P.R. China.
Clin Chem Lab Med. 2018 Jan 26;56(2):350-355. doi: 10.1515/cclm-2017-0282.
Recent studies have suggested that omentin-1 plays a critical role in the development of cardiovascular disease. However, reported findings are inconsistent, and no study has evaluated the association between omentin-1 levels and a poor functional outcome after ischemic stroke onset.
A total of 266 acute ischemic stroke patients were included in this study. All patients were prospectively followed up for 3 months after acute ischemic stroke onset and a poor functional outcome was defined as a major disability or death occurring during the follow-up period. A multivariable logistic model was used to evaluate the association between serum omentin-1 levels and the functional outcome of ischemic stroke patients at 3 months.
Ischemic stroke patients with poor functional outcome had significantly lower levels of serum omentin-1 than patients without poor functional outcome at the 3-month follow-up (50.2 [40.2-59.8] vs. 58.3 [44.9-69.6] ng/mL, p<0.01). Subjects in the highest tertile of serum omentin-1 levels had a 0.38-fold risk of having poor functional outcome, compared with those in the lowest tertile (p<0.05). A negative association between omentin-1 levels and poor functional outcome was found (p for trend=0.02). The net reclassification index was significantly improved in predicting poor functional outcome when omentin-1 data was added to the multivariable logistic regression model.
Higher omentin-1 levels at baseline were negatively associated with poor functional outcome among ischemic stroke patients. Omentin-1 may represent a biomarker for predicting poor functional outcome of acute ischemic stroke patients.
最近的研究表明，网膜素-1 在心血管疾病的发展中起着关键作用。然而，报道的结果不一致，没有研究评估网膜素-1 水平与缺血性脑卒中发病后不良功能结局之间的关系。
本研究共纳入 266 例急性缺血性脑卒中患者。所有患者均在急性缺血性脑卒中发病后进行前瞻性随访 3 个月，随访期间发生主要残疾或死亡定义为不良功能结局。采用多变量逻辑模型评估血清网膜素-1 水平与缺血性脑卒中患者 3 个月时功能结局的关系。
在 3 个月随访时，具有不良功能结局的缺血性脑卒中患者的血清网膜素-1 水平显著低于无不良功能结局的患者（50.2[40.2-59.8]ng/ml 比 58.3[44.9-69.6]ng/ml，p<0.01）。血清网膜素-1 水平最高三分位的患者发生不良功能结局的风险是最低三分位的 0.38 倍（p<0.05）。血清网膜素-1 水平与不良功能结局呈负相关（趋势检验 p=0.02）。当将网膜素-1 数据加入多变量逻辑回归模型时，预测不良功能结局的净重新分类指数显著提高。
基线时较高的网膜素-1 水平与缺血性脑卒中患者的不良功能结局呈负相关。网膜素-1 可能是预测急性缺血性脑卒中患者不良功能结局的生物标志物。
