Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, China.
Brain Behav. 2020 Jul;10(7):e01678. doi: 10.1002/brb3.1678. Epub 2020 Jun 1.
Previous studies have shown that adipocytokines are associated with atherosclerosis, diagnosis, and functional prognosis after ischemic stroke. However, few studies have investigated the relationship between omentin-1 and atherosclerotic acute cerebral infarction (ACI).
In this study, we investigated the association between serum omentin-1 levels at admission and severity, infarction volume, and functional prognosis of patients 90 days after atherosclerotic ACI.
A total of 109 patients with atherosclerotic ACI were enrolled. Serum omentin-1 levels at admission were lower in patients with ACI than those in healthy controls (47.18 ± 13.64 vs. 56.27 ± 34.44 ng/ml, p = .014). Serum omentin-1 levels at admission were negatively correlated with severity of ACI (r = -.271, p = .004) and infarction volume (r = -.264, p = .006), respectively. Moreover, serum omentin-1 levels were lower in the poor functional prognosis group than those in the good functional prognosis group in patients with large artery and small artery atherosclerotic ACI. In a logistic regression analysis, higher serum omentin-1 level (>43.10 ng/ml) at admission was negatively associated with a poor functional prognosis 90 days after atherosclerotic ACI.
Serum omentin-1 levels at admission were significantly lower among patients with ACI. A higher plasma omentin-1 level (>43.10 ng/ml) was negatively associated with poor functional prognosis 90 days after atherosclerotic ACI. Further studies are needed to investigate the pathophysiological mechanism of omentin-1 in affecting attacks and prognosis of ACI as well as to confirm the value of plasma omentin-1 level as a potential biomarker.
既往研究表明脂肪细胞因子与动脉粥样硬化、缺血性脑卒中的诊断和功能预后相关。然而，关于网膜素-1与动脉粥样硬化性急性脑梗死（ACI）的关系，研究甚少。
本研究旨在探讨入院时血清网膜素-1水平与动脉粥样硬化性 ACI 患者发病 90 天后严重程度、梗死体积及功能预后的关系。
共纳入 109 例动脉粥样硬化性 ACI 患者。ACI 组患者入院时血清网膜素-1水平低于健康对照组（47.18±13.64 比 56.27±34.44 ng/ml，p=0.014）。入院时血清网膜素-1水平与 ACI 严重程度（r=-0.271，p=0.004）和梗死体积（r=-0.264，p=0.006）呈负相关。此外，大动脉粥样硬化性 ACI 和小动脉粥样硬化性 ACI 患者中，预后不良组入院时血清网膜素-1水平低于预后良好组。在 logistic 回归分析中，入院时较高的血清网膜素-1水平（＞43.10 ng/ml）与动脉粥样硬化性 ACI 发病 90 天后的不良功能预后呈负相关。
动脉粥样硬化性 ACI 患者入院时血清网膜素-1水平显著降低。入院时较高的血浆网膜素-1水平（＞43.10 ng/ml）与动脉粥样硬化性 ACI 发病 90 天后的不良功能预后呈负相关。需要进一步研究网膜素-1影响 ACI 发作和预后的病理生理学机制，并确认血浆网膜素-1水平作为潜在生物标志物的价值。
