Spurling N W
Comp Biochem Physiol A Comp Physiol. 1986;83(4):755-60. doi: 10.1016/0300-9629(86)90723-1.
In the plasma of beagles known to be homozygotes for hereditary blood coagulation factor-VII deficiency, antibody neutralization assays indicate only slightly greater quantities of factor-VII related antigen than are detected by conventional assays of procoagulant activity. Plasma of one dog was depleted of factor-VII procoagulant activity by exposure to an immobilized antibody; the low level of activity originally present was then verified by titration with normal plasma. The plasma defect results from an incomplete deletion of synthesis.
在已知为遗传性凝血因子 VII 缺乏纯合子的比格犬血浆中，抗体中和试验表明，与通过常规促凝血活性测定法检测到的相比，因子 VII 相关抗原的量仅略多。通过暴露于固定化抗体，使一只狗的血浆中的因子 VII 促凝血活性耗尽；然后用正常血浆滴定来验证最初存在的低活性水平。血浆缺陷是由于合成不完全缺失所致。
