比格犬群体中凝血因子 VII 先天性缺陷的鉴定：血浆的临床应用。
Identification of a congenital defect of factor VII in a colony of beagle dogs: the clinical use of the plasma.
作者信息
Poller L, Thomson J M, Sear C H, Thomas W
出版信息
J Clin Pathol. 1971 Oct;24(7):626-32. doi: 10.1136/jcp.24.7.626.
Abstract
A severe, pure deficiency of factor VII has been defined in haematological and biochemical terms in the Alderley Park colony of beagle dogs. By modification of the conventional factor VII assay to improve its specificity an apparent low activity of between 1 and 2.5% of the normal beagle has been found. When this plasma is used as a substrate for factor VII assays it compares well with human factor VII-deficient plasma in the measurement of both raised and depressed factor VII activity. It also appears to be a valuable reagent in the quality control of tissue thromboplastin extracts.
摘要
在比格犬的奥尔德利公园犬群中，已从血液学和生物化学角度对严重的、单纯的凝血因子VII缺乏进行了定义。通过改进传统的凝血因子VII检测方法以提高其特异性，发现比格犬的活性明显较低，仅为正常比格犬的1%至2.5%。当将这种血浆用作凝血因子VII检测的底物时，在测量升高和降低的凝血因子VII活性方面，它与人类凝血因子VII缺乏血浆相比效果良好。它似乎也是组织凝血活酶提取物质量控制中的一种有价值的试剂。
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Identification of a congenital defect of factor VII in a colony of beagle dogs: the clinical use of the plasma.比格犬群体中凝血因子 VII 先天性缺陷的鉴定：血浆的临床应用。
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