犬特有的凝血因子 VII ELISA 检测法。
Canine specific ELISA for coagulation factor VII.
机构信息
Department of Small Animal Clinical Sciences, Faculty of Life Sciences, University of Copenhagen, Copenhagen DK-1870, Denmark.
出版信息
Vet J. 2011 Dec;190(3):352-8. doi: 10.1016/j.tvjl.2010.11.010. Epub 2011 Jan 8.
Abstract
Canine coagulation factor VII (FVII) deficiency can be hereditary or acquired and may cause life threatening bleeding episodes if untreated. FVII procoagulant activity can be measured by FVII activity (FVII:C), but assays for measurement of canine specific FVII antigen (FVII:Ag) have not been available to date. In this study, a canine specific ELISA for measurement of FVII:Ag in plasma was developed and validated. The FVII:Ag ELISA correctly diagnosed homozygous and heterozygous hereditary FVII deficiency. Together with activity based assays, such as FVII:C, the FVII:Ag ELISA should be valuable in the diagnosis of hereditary canine FVII deficiency.
摘要
犬凝血因子 VII（FVII）缺乏症可分为遗传性或获得性，如果未经治疗，可能会导致危及生命的出血事件。FVII 促凝活性可通过 FVII 活性（FVII:C）来测量，但目前还没有用于测量犬特异性 FVII 抗原（FVII:Ag）的检测方法。在这项研究中，开发并验证了一种用于测量血浆中 FVII:Ag 的犬特异性 ELISA。FVII:Ag ELISA 可正确诊断纯合子和杂合子遗传性 FVII 缺乏症。与基于活性的检测方法（如 FVII:C）一起，FVII:Ag ELISA 应该对遗传性犬 FVII 缺乏症的诊断具有重要价值。
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