Cochrane Graham D, Sundman Mark H, Hall Eric E, Kostek Matthew C, Patel Kirtida, Barnes Kenneth P, Ketcham Caroline J
Department of Exercise Science, Elon University, Elon, North Carolina.
Department of Psychology, University of Arizona, Tucson, Arizona.
Clin J Sport Med. 2018 Mar;28(2):125-129. doi: 10.1097/JSM.0000000000000443.
This study investigates 4 single-nucleotide polymorphisms [Apolipoprotein E (APOE), APOE promoter, catechol-O-methyl transferase (COMT), and dopamine D2 receptor] that have been implicated in concussion susceptibility and/or cognitive ability in collegiate student-athletes.
Cross-sectional study.
Neuroscience laboratory at Elon University.
Two hundred fifty division I collegiate student-athletes (66 women, 184 men) from various sports.
All participants completed Immediate Postconcussion Assessment and Cognitive Testing (ImPACT) testing at baseline concussion testing and had a buccal swab taken for DNA for genotyping.
Self-reported history of concussions and neurocognitive performance were taken from ImPACT.
Individuals carrying an ε4 allele in their APOE gene had a significantly slower reaction time (P = 0.001). Individuals homozygous for the Val allele of the COMT gene showed significantly worse impulse control scores (P = 0.014). None of the genotypes were able to predict self-reported concussion history in collegiate student-athletes.
These results indicate that certain genotypes may influence performance on cognitive testing at baseline and that the APOE genotypes may not influence concussion susceptibility as suggested by past studies.
本研究调查了4种单核苷酸多态性[载脂蛋白E（APOE）、APOE启动子、儿茶酚-O-甲基转移酶（COMT）和多巴胺D2受体]，这些多态性与大学生运动员的脑震荡易感性和/或认知能力有关。
横断面研究。
伊隆大学神经科学实验室。
来自不同运动项目的250名一级大学生运动员（66名女性，184名男性）。
所有参与者在基线脑震荡测试时完成了脑震荡后即刻评估和认知测试（ImPACT），并采集颊拭子进行DNA基因分型。
从ImPACT中获取脑震荡的自我报告病史和神经认知表现。
APOE基因携带ε4等位基因的个体反应时间明显较慢（P = 0.001）。COMT基因Val等位基因纯合的个体冲动控制得分明显较差（P = 0.014）。没有一种基因型能够预测大学生运动员自我报告的脑震荡病史。
这些结果表明，某些基因型可能会影响基线时认知测试的表现，并且APOE基因型可能不会像过去研究所表明的那样影响脑震荡易感性。
