去屏蔽细胞外体 RNA 会引发肿瘤生长和转移。

Unshielding Exosomal RNA Unleashes Tumor Growth And Metastasis.

机构信息

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medical College, New York, NY, USA; Division of Medical Oncology, Departments of Internal Medicine and Pharmacology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.

出版信息

Cell. 2017 Jul 13;170(2):223-225. doi: 10.1016/j.cell.2017.06.047.

DOI:10.1016/j.cell.2017.06.047

PMID:28708994

Abstract

Reciprocal interactions between tumor cells and their microenvironment drive cancer progression and therapy resistance. In this issue, Nabet et al. demonstrate that dynamic feedback between tumor and stroma subverts normal inflammatory responses by triggering the release of exosomes containing unshielded RNAs that activate pattern recognition receptors, thereby promoting tumor growth and metastasis.

摘要

肿瘤细胞与其微环境之间的相互作用促进了癌症的进展和治疗耐药性。在本期杂志中，Nabet 等人表明，肿瘤和基质之间的动态反馈通过触发含有未屏蔽 RNA 的外泌体的释放，激活模式识别受体，从而促进肿瘤生长和转移，破坏了正常的炎症反应。