State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, China.
Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Sci Total Environ. 2017 Dec 31;607-608:578-585. doi: 10.1016/j.scitotenv.2017.07.003. Epub 2017 Jul 27.
Humans are potentially exposed to many environmental pollutants, many of which may cause adverse health effects, especially to pregnant women and their fetuses. In this study, 11 environmental pollutants from three different chemical classes, including benzophenones, parabens and triclosan were measured in 627 urine samples collected from 209 pregnant women to evaluate exposure and trends as a function of pregnancy stage. Methylparaben (MeP), ethylparaben, propylparaben (PrP), butylparaben, 2,4-dihydroxybenzophenone (BP-1), 2-hydroxy-4-methoxybenzophenone (BP-3) and 4-hydroxybenzophenone were detected in >50% samples. The concentrations of BP-1 and BP-3 (Spearman's r=0.57, p<0.01) and those of MeP and PrP (Spearman's r=0.68, p<0.01) were found to be correlated. The urinary concentrations of BP-1 and BP-3 in the first trimester were significantly higher than those in the second or third trimester (Mann-Whitney U test, p<0.05). These findings provide valuable information for improving the prediction of maternal exposure to these emerging pollutants and for assessing their potential health risks to the mother as well as the offspring.
人类可能会接触到许多环境污染物，其中许多可能会对健康造成不良影响，尤其是对孕妇及其胎儿。在这项研究中，我们检测了 209 名孕妇的 627 份尿液样本中的 11 种环境污染物，这些污染物来自 3 种不同的化学物质类别，包括二苯甲酮类、对羟基苯甲酸酯类和三氯生，以评估暴露情况及其随妊娠阶段的变化趋势。在>50%的样本中检测到了甲基对羟基苯甲酸酯（MeP）、乙基对羟基苯甲酸酯、丙基对羟基苯甲酸酯（PrP）、丁基对羟基苯甲酸酯、2,4-二羟基二苯甲酮（BP-1）、2-羟基-4-甲氧基二苯甲酮（BP-3）和 4-羟基二苯甲酮。BP-1 和 BP-3 的浓度（Spearman's r=0.57，p<0.01）以及 MeP 和 PrP 的浓度（Spearman's r=0.68，p<0.01）呈正相关。妊娠早期尿液中 BP-1 和 BP-3 的浓度明显高于妊娠中期或晚期（Mann-Whitney U 检验，p<0.05）。这些发现为改善对这些新兴污染物的母体暴露预测以及评估它们对母亲和后代的潜在健康风险提供了有价值的信息。
