人类假饲时胆囊排空反应。

Gallbladder emptying response to sham feeding in humans.

作者信息

Fisher R S, Rock E, Malmud L S

出版信息

Gastroenterology. 1986 Jun;90(6):1854-7. doi: 10.1016/0016-5085(86)90252-0.

Abstract

Cholescintigraphy, using 99mTc-HIDA, was employed to determine the gallbladder emptying response to sham feeding of a steak and potato meal, and to compare it with the emptying responses to direct cholinergic stimulation by bethanechol and to ingestion of the test meal. The maximal cumulative gallbladder emptying response to sham feeding was 44.1% + 10.1%, which was not significantly different from the response to bethanechol. Cholinergic blockade with atropine eliminated the emptying response to sham feeding. Also, sham feeding did not stimulate gallbladder emptying in patients with vagotomy. This study suggests that intact vagus nerves and cholinergic pathways are required in order for the gallbladder to respond to sham feeding. The precise mechanism for this effect has not been elucidated.

摘要

使用99mTc-HIDA进行的胆管闪烁显像术，用于确定胆囊对假进食牛排和土豆餐的排空反应，并将其与对氨甲酰甲胆碱直接胆碱能刺激的排空反应以及对试验餐摄入的排空反应进行比较。假进食时胆囊的最大累积排空反应为44.1% + 10.1%，这与对氨甲酰甲胆碱的反应无显著差异。用阿托品进行胆碱能阻断消除了假进食时的排空反应。此外，迷走神经切断术患者的假进食并未刺激胆囊排空。这项研究表明，胆囊要对假进食作出反应，需要完整的迷走神经和胆碱能通路。这种效应的确切机制尚未阐明。