生长抑素抑制人皮肤吗啡刺激的促甲状腺激素释放。

Somatostatin inhibits the dermorphin-stimulated thyrotropin release in man.

作者信息

degli Uberti E C, Roti E, Trasforini G, Salvadori S, Margutti A, Robuschi G, Tomatis R, Gnudi A, Pansini R, Braverman L E

出版信息

Horm Res. 1986;23(4):207-12. doi: 10.1159/000180325.

DOI:10.1159/000180325

PMID:2870974

Abstract

We have studied the effect of the intravenous administration of somatostatin (SRIF) on the thyrotropin (TSH) response to intravenous dermorphin (D), a new potent opioid peptide, in 7 healthy men. D significantly increased the serum TSH concentration. SRIF administration prior to, during and after D completely prevented the D-induced rise in serum TSH. These results confirm that D stimulates TSH release in man and that this stimulatory effect can be prevented by SRIF.

摘要

我们研究了静脉注射生长抑素（SRIF）对7名健康男性静脉注射新型强效阿片肽——皮啡肽（D）后促甲状腺激素（TSH）反应的影响。D显著提高了血清TSH浓度。在D注射前、注射期间及注射后给予SRIF，完全阻止了D诱导的血清TSH升高。这些结果证实，D可刺激人体TSH释放，且这种刺激作用可被SRIF阻止。