视黄酸诱导的正常及白血病髓系细胞中的基因表达。
Retinoic acid-induced gene expression in normal and leukemic myeloid cells.
作者信息
Murtaugh M P, Dennison O, Stein J P, Davies P J
出版信息
J Exp Med. 1986 May 1;163(5):1325-30. doi: 10.1084/jem.163.5.1325.
Abstract
Retinoic acid has been shown to induce large accumulations of tissue transglutaminase in cultured myeloid cells. Addition of retinoic acid to mouse resident peritoneal macrophages increased the level of tissue transglutaminase mRNA within 30-60 min. Retinoic acid also increased tissue transglutaminase mRNA levels in human promyelocytic leukemia (HL-60) cells. These studies show that retinoic acid can induce acute alterations in specific gene expression in both normal and leukemic myeloid cells.
摘要
维甲酸已被证明可在培养的髓细胞中诱导组织转谷氨酰胺酶大量积累。向小鼠腹腔巨噬细胞中添加维甲酸可在30 - 60分钟内提高组织转谷氨酰胺酶mRNA水平。维甲酸还可提高人早幼粒细胞白血病（HL - 60）细胞中的组织转谷氨酰胺酶mRNA水平。这些研究表明，维甲酸可在正常和白血病髓细胞中诱导特定基因表达的急性改变。
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Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid.维甲酸诱导人早幼粒细胞白血病细胞系（HL-60）分化
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Preparation and use of nuclease-treated rabbit reticulocyte lysates for the translation of eukaryotic messenger RNA.用于真核生物信使核糖核酸翻译的经核酸酶处理的兔网织红细胞裂解物的制备与应用
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Role of retinoids in differentiation and carcinogenesis.维甲酸在分化和致癌过程中的作用。
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