Clifton William, Akinduro Oluwaseun Oluwadara, Lopez-Chiriboga Sebastian, Whitaker Dale Alan, Reimer Ronald
Department of Neurological Surgery, Mayo Clinic Florida, Jacksonville, Florida, USA.
Department of Neurological Surgery, Mayo Clinic Florida, Jacksonville, Florida, USA.
World Neurosurg. 2017 Oct;106:1053.e1-1053.e5. doi: 10.1016/j.wneu.2017.07.001. Epub 2017 Jul 12.
Primary central nervous system (CNS) histiocytic sarcoma is an extremely rare lymphoproliferative disorder that affects the CNS and behaves aggressively. Only 27 cases of primary CNS histiocytic sarcoma have been reported. The paucity of literature on this entity has made diagnosis and treatment difficult both for the surgeon and the pathologist.
In this case of primary CNS histiocytic sarcoma, a middle-aged woman presented from an outside institution with a supposed cerebellar abscess. Intraoperative frozen pathology was initially interpreted as high-grade glioma; however, final pathology demonstrated histiocytic sarcoma.
This report makes a significant contribution to the literature on this rare malignant disease by outlining a similar presentation among several cases and providing a thorough overview of existing criteria for diagnosis and management.
原发性中枢神经系统（CNS）组织细胞肉瘤是一种极其罕见的影响中枢神经系统且侵袭性强的淋巴增殖性疾病。仅报道过27例原发性中枢神经系统组织细胞肉瘤。关于该实体的文献匮乏，给外科医生和病理学家的诊断及治疗都带来了困难。
在这例原发性中枢神经系统组织细胞肉瘤病例中，一名中年女性从外院转来，疑似患有小脑脓肿。术中冰冻病理最初诊断为高级别胶质瘤；然而，最终病理显示为组织细胞肉瘤。
本报告通过概述几例病例中的相似表现，并全面综述现有的诊断和管理标准，为关于这种罕见恶性疾病的文献做出了重要贡献。
