阿片肽在糖尿病中的生物学功能及新兴治疗作用概述
An overview on biological functions and emerging therapeutic roles of apelin in diabetes mellitus.
作者信息
Alipour Farzaneh Ghafarian, Ashoori Mohamad Reza, Pilehvar-Soltanahmadi Younes, Zarghami Nosratollah
机构信息
Department of Clinical Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Clinical Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Diabetes Metab Syndr. 2017 Dec;11 Suppl 2:S919-S923. doi: 10.1016/j.dsx.2017.07.016. Epub 2017 Jul 4.
Type 2 diabetes mellitus is a common type of diabetes and considered as multifactorial disease. Apelin is an adipokine which secreted from white adipose tissue and involved in various functions such as insulin sensitivity and food intake. Many studies showed that apelin has a crucial role in diabetes and its concentration will change in relation with insulin resistance. In this review, we will discuss the roles of apelin in energy metabolism and pathogenesis of diabetes and explain why apelin can be a good candidate adipokine to promoting insulin sensitivity.
2型糖尿病是一种常见的糖尿病类型，被认为是多因素疾病。Apelin是一种由白色脂肪组织分泌的脂肪因子，参与多种功能，如胰岛素敏感性和食物摄入。许多研究表明，Apelin在糖尿病中起关键作用，其浓度会随着胰岛素抵抗而变化。在这篇综述中，我们将讨论Apelin在能量代谢和糖尿病发病机制中的作用，并解释为什么Apelin可以成为促进胰岛素敏感性的良好候选脂肪因子。
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