Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, PR China.
Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, PR China.
Nanomedicine. 2017 Oct;13(7):2271-2280. doi: 10.1016/j.nano.2017.07.002. Epub 2017 Jul 13.
Chemotherapy and photothermal therapy can be efficiently integrated to achieve enhanced antitumor efficacy by using carbon nanotubes (CNTs) which are super in delivering drug and converting near infrared radiation (NIR) into heat. We previously developed an innovative TAT-chitosan functionalized MWCNTs (MWCNTs/TC) based drug delivery system for doxorubicin (DOX) and preliminarily investigated its release profile and antitumor effect. In the present study, the application potential of MWCNTs/DOX/TC in chemo-photothermal combination therapy was further explored. The in vitro drug release, photothermal effect, cellular uptake and cytotoxicity were assessed. The in vivo anti-tumor effect of MWCNTs/DOX/TC was further evaluated by noninvasive bioluminescence imaging. It was demonstrated that this innovative drug delivery system not only realized a conspicuously sustained release of DOX, but also retained the optical properties of MWCNTs for a high photothermal effect upon NIR irradiation, and exhibited remarkably enhanced anti-tumor efficacy through the synergistic function of chemotherapy and photothermal ablation.
化疗和光热疗法可以通过使用碳纳米管（CNTs）有效地整合，以实现增强的抗肿瘤疗效，碳纳米管在输送药物和将近红外辐射（NIR）转化为热方面非常出色。我们之前开发了一种基于 TAT-壳聚糖功能化多壁碳纳米管（MWCNTs/TC）的新型药物输送系统，用于阿霉素（DOX），并初步研究了其释放特性和抗肿瘤作用。在本研究中，进一步探索了 MWCNTs/DOX/TC 在化疗-光热联合治疗中的应用潜力。评估了体外药物释放、光热效应、细胞摄取和细胞毒性。通过无创生物发光成像进一步评估了 MWCNTs/DOX/TC 在体内的抗肿瘤作用。结果表明，这种创新的药物输送系统不仅实现了 DOX 的显著持续释放，而且保留了 MWCNTs 的光学特性，在近红外辐射下具有高光热效应，并通过化疗和光热消融的协同作用显著增强了抗肿瘤疗效。
