Kok D J, Papapoulos S E, Bijvoet O L
Lancet. 1986 May 10;1(8489):1056-8. doi: 10.1016/s0140-6736(86)91329-2.
In 7 highly recurrent calcium oxalate stone-formers and 10 healthy subjects the effects of urine on three processes of calcium oxalate monohydrate crystallisation--solubility, crystal growth, and crystal agglomeration--were studied. The urine of the stone-formers showed low calcium oxalate solubility and normal crystal growth inhibition, but lacked the ability to inhibit crystal agglomeration. As the sole metabolic abnormality, all stone-formers showed hypocitraturia. Normalisation of urinary citrate concentration resulted both in vitro and in vivo in a significant rise in agglomeration inhibition. These results show that inhibition of agglomeration is a very important, probably citrate-regulated, process in calcium oxalate stone formation.
在7名草酸钙结石复发率高的患者和10名健康受试者中，研究了尿液对一水草酸钙结晶的三个过程——溶解度、晶体生长和晶体聚集——的影响。结石患者的尿液显示出低草酸钙溶解度和正常的晶体生长抑制能力，但缺乏抑制晶体聚集的能力。作为唯一的代谢异常，所有结石患者均表现为低枸橼酸尿症。尿枸橼酸盐浓度正常化在体外和体内均导致聚集抑制显著增加。这些结果表明，抑制聚集是草酸钙结石形成中一个非常重要的、可能由枸橼酸盐调节的过程。
