Tiselius H G, Fornander A M, Nilsson M A
Department of Urology, University Hospital, Linköping, Sweden.
Urol Res. 1993;21(5):363-6. doi: 10.1007/BF00296838.
The rate of crystal sedimentation in a suspension of calcium oxalate monohydrate (COM) crystals was determined spectrophotometrically in the presence and absence of dialysed urine and citrate. A reduced rate of crystal sedimentation after stirring was recorded in suspensions containing citrate in concentrations between 0.33 and 1.67 mmol/l. The sedimentation rate was reduced in the presence of a 0.3-3.3% concentration of dialysed urine, with increased inhibition of crystal sedimentation when the concentration of urine was increased. A comparison of the inhibition of COM crystal sedimentation in whole urine and in dialysed urine from normal subjects and stone-formers disclosed significantly higher values (P < 0.05) in the dialysed urine. The results support previous observations that physiological concentrations of citrate might efficiently inhibit the aggregation of COM crystals. Furthermore even low concentrations of both whole urine and dialysed urine are apparently very efficient inhibitors of COM crystal aggregation.
在有无透析尿液和柠檬酸盐存在的情况下，通过分光光度法测定了一水合草酸钙（COM）晶体悬浮液中的晶体沉降速率。在含有浓度为0.33至1.67 mmol/l柠檬酸盐的悬浮液中，搅拌后记录到晶体沉降速率降低。当透析尿液浓度为0.3 - 3.3%时，沉降速率降低，且随着尿液浓度增加，晶体沉降的抑制作用增强。对正常人和结石形成者的全尿和透析尿中COM晶体沉降抑制情况的比较显示，透析尿中的抑制值显著更高（P < 0.05）。这些结果支持了先前的观察结果，即生理浓度的柠檬酸盐可能有效抑制COM晶体的聚集。此外，即使是低浓度的全尿和透析尿显然也是COM晶体聚集的非常有效的抑制剂。
