Lee Sanghyun, Baldridge Megan T
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, United States.
Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, United States.
Front Immunol. 2017 Jun 30;8:749. doi: 10.3389/fimmu.2017.00749. eCollection 2017.
Interferon-lambda (IFN-λ) is a recently described cytokine found to be of critical importance in innate immune regulation of intestinal viruses. Endogenous IFN-λ has potent antiviral effects and has been shown to control multiple intestinal viruses and may represent a factor that contributes to human variability in response to infection. Importantly, recombinant IFN-λ has therapeutic potential against enteric viral infections, many of which lack other effective treatments. In this mini-review, we describe recent advances regarding IFN-λ-mediated regulation of enteric viruses with important clinical relevance including rotavirus, reovirus, and norovirus. We also briefly discuss IFN-λ interactions with other cytokines important in the intestine, and how IFN-λ may play a role in regulation of intestinal viruses by the commensal microbiome. Finally, we indicate currently outstanding questions regarding IFN-λ control of enteric infections that remain to be explored to enhance our understanding of this important immune molecule.
干扰素-λ（IFN-λ）是一种最近被描述的细胞因子，发现在肠道病毒的固有免疫调节中至关重要。内源性IFN-λ具有强大的抗病毒作用，已被证明可控制多种肠道病毒，可能是导致人类对感染反应存在差异的一个因素。重要的是，重组IFN-λ对肠道病毒感染具有治疗潜力，其中许多感染缺乏其他有效治疗方法。在本综述中，我们描述了IFN-λ介导的对具有重要临床相关性的肠道病毒（包括轮状病毒、呼肠孤病毒和诺如病毒）调节的最新进展。我们还简要讨论了IFN-λ与肠道中其他重要细胞因子的相互作用，以及IFN-λ如何通过共生微生物群在肠道病毒调节中发挥作用。最后，我们指出了关于IFN-λ控制肠道感染目前仍未解决的问题，这些问题有待探索，以增进我们对这一重要免疫分子的理解。
