BioSensor Technologies, AIT Austrian Institute of Technology, Vienna, Austria.
Departments of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Stem Cells Transl Med. 2017 Aug;6(8):1730-1739. doi: 10.1002/sctm.17-0055. Epub 2017 Jul 17.
Growing interest in extracellular vesicles (EVs, including exosomes and microvesicles) as therapeutic entities, particularly in stem cell-related approaches, has underlined the need for standardization and coordination of development efforts. Members of the International Society for Extracellular Vesicles and the Society for Clinical Research and Translation of Extracellular Vesicles Singapore convened a Workshop on this topic to discuss the opportunities and challenges associated with development of EV-based therapeutics at the preclinical and clinical levels. This review outlines topic-specific action items that, if addressed, will enhance the development of best-practice models for EV therapies. Stem Cells Translational Medicine 2017;6:1730-1739.
人们对细胞外囊泡（EV，包括外泌体和微囊泡）作为治疗实体的兴趣日益浓厚，特别是在与干细胞相关的方法中，这凸显了标准化和协调开发工作的必要性。国际细胞外囊泡学会和新加坡细胞外囊泡临床研究与转化学会的成员就这一主题召开了一次研讨会，讨论了在临床前和临床水平开发基于 EV 的治疗方法的相关机遇和挑战。本综述概述了特定主题的行动计划，如果得到解决，将有助于开发 EV 疗法的最佳实践模型。《干细胞转化医学》2017；6:1730-1739。
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