Tsang A S, Dart A J, Sole-Guitart A, Dart C M, Perkins N R, Jeffcott L B
Research and Clinical Trials Unit, University Veterinary Teaching Hospital Camden, University of Sydney, 410 Werombi Road, Camden, New South Wales 2570, Australia.
School of Veterinary Science, The University of Queensland, Gatton, Queensland, Australia.
Aust Vet J. 2017 Sep;95(9):333-337. doi: 10.1111/avj.12616. Epub 2017 Jul 17.
To compare the effect of application of manuka honey with unique manuka factor (UMF) 5 or 20 with a generic multifloral honey on equine wound healing variables.
Two full-thickness skin wounds (2.5 × 2.5 cm) were created on the metatarsus of both hindlimbs of eight Standardbred horses. The wounds on each horse were assigned to 1 of 4 treatments: UMF20 (UMF20) and UMF5 (UMF5) manuka honey; generic multifloral honey (GH); and a saline control. Bandages were changed daily for 12 days, after which treatment was stopped and the bandages were removed. Wound area was measured on day 1, then weekly until day 42. Overall wound healing rate (cm /day) and time to complete healing were recorded.
There was no difference in wound area for any of the treatments on any measurement day except for day 21, where the mean wound area for wounds treated with UMF20 was smaller than the mean wound area for the UMF5-treated wounds (P = 0.031). There was no difference in mean (± SE) overall healing rate (cm /day) among the treatment groups. There were differences in mean (± SE) days to complete healing. Wounds treated with UMF20 healed faster than wounds treated with GH (P = 0.02) and control wounds (P = 0.01).
Treatment of wounds with UMF20 reduced overall wound healing time compared with wounds treated with GH and control wounds. However, using this model the difference in the overall time to complete healing was small.
比较含有独特麦卢卡因子（UMF）5或20的麦卢卡蜂蜜与普通多花蜂蜜对马伤口愈合变量的影响。
在8匹标准赛马的双后肢跗骨上制造两个全层皮肤伤口（2.5×2.5厘米）。每匹马的伤口被分配到4种处理中的1种：UMF20（UMF20）和UMF5（UMF5）麦卢卡蜂蜜；普通多花蜂蜜（GH）；以及生理盐水对照。绷带每天更换，持续12天，之后停止处理并拆除绷带。在第1天测量伤口面积，然后每周测量直至第42天。记录总体伤口愈合率（厘米/天）和完全愈合时间。
除第21天外，在任何测量日，任何处理的伤口面积均无差异，在第21天，用UMF20处理的伤口平均面积小于用UMF5处理的伤口平均面积（P = 0.031）。各处理组之间的平均（±标准误）总体愈合率（厘米/天）无差异。完全愈合的平均（±标准误）天数存在差异。用UMF20处理的伤口比用GH处理的伤口愈合更快（P = 0.02），且比对照伤口愈合更快（P = 0.01）。
与用GH处理的伤口和对照伤口相比，用UMF20处理伤口可缩短总体伤口愈合时间。然而，在该模型中，完全愈合的总体时间差异较小。
